Vertebral Metastases: Assessment with Apparent Diffusion Coefficient

Abstract

The authors evaluated the apparent diffusion coefficient (ADC) in the assessment of vertebral metastases and acute vertebral compression fractures in 22 patients with known or suspected vertebral metastases. On the basis of significantly (P <.03) different ADCs, vertebral metastases (0.69 x 10(-3) mm2/sec) and pathologic compression fractures (0.65 x 10(-3) mm2/sec) can be safely distinguished from vertebral bodies (1.66 x 10(-3) mm2/sec) and benign compression fractures (1.62 x 10(-3) mm2/sec). Thus, the use of ADCs may increase the specificity of magnetic resonance imaging in these patients.

The Potential Role of Apparent Diffusion Coefficient Values in the Differentiation of Tuberculous and Malignant Lymph Nodes of Neck - In Correlation with Histopathology

“…Regular lymph nodes showed ADC value of 1.21+/-0.24×10-3mm2/s which was significantly higher than the diffusivity of metastatic lymph nodes (ADC value: 0.59+/-0.27×10-3mm2/s). Similar results were published by other authors also [35][36][37][38] .…”

“…This motion results in a phase shift of the sensitized water protons and consecutively in a signal loss on DWI. [31,35,38] .…”

Can Quantitative Diffusion-Weighted MR Imaging Differentiate Benign and Malignant Cold Thyroid Nodules? Initial Results in 25 Patients

“…For quantitative analysis of tissue-specific diffusion capacities, the ADC was calculated according to the following equation 22 respectively) in the user-defined regions of interest. 20 The region of interest was placed in the pathologic lesion on DWI by an experienced head and neck radiologist, who matched the SI changes on T1-and T2-weighted turbo spin-echo images.…”

Improved Detection of Skull Metastasis with Diffusion-Weighted MR Imaging

“…3,4 DWI has also been used for a wide range of other pathologies including metastasis to vertebral bodies, [5][6][7][8][9][10][11][12][13][14][15][16][17] though there has been controversy on this subject. 18,19 DWI may be helpful to differentiate pathologic compression fractures related to metastases from benign osteoporotic compression fractures.…”