Vertebral metastases and an equivocal bone scan

An unexpected supraclavicular swelling

“…Plausible explanations for false negative findings are pure osteolytic lesions growing rapidly, when bone turnover is slow, or when the site is avascular. Hence in case of equivocal findings alternative methods in terms of traditional needle biopsy [9] or more recently magnetic resonance imaging [10] can be used for diagnosis. Sometimes abnormal biochemistry can indicate bony metastases e.g.…”

Impact of bone SPECT-CT imaging on evaluation of lower extremities' abnormalities

“…6 Correlation of bone scanning with other radiological exams may be required to increase the specificity and accuracy of identification of the etiology of bony lesions. [7][8][9][10] Similarly, other radiologic imaging modalities are usually needed, in conjunction with bone scanning, for evaluation of response to treatment in bony metastases. [11][12][13] The value of single photon emission computed tomography-computed tomography (SPECT-CT) for evaluating bone lesions on bone scans has been investigated in different regions of the body and for different indications.…”

Early Response of Breast Cancer Bone Metastases to Chemotherapy Evaluated With MR Imaging

“…Early and objective assessment of the response to therapy in this group of patients is therefore important, so that if a patient has failed to respond, the treatment can be altered. MR imaging, being a highly sensitive technique in detection of bone metastases (2–4, 13, 14, 16), is also promising for accurate assessment of the therapeutic response of bone metastases. Different MR techniques have been studied in this regard (6, 7, 27).…”