Vertebral Fractures and Mortality in Older Women

Kado, Deborah M.; Browner, Warren S.; Palermo, Lisa; Nevitt, Michael C.; Genant, Harry K.; Cummings, Steven R.

doi:10.1001/archinte.159.11.1215

Cited by 925 publications

(198 citation statements)

References 28 publications

(15 reference statements)

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…Vertebral fracture and osteoporosis frequently have a significant impact on the patient's physical activity and may reduce quality of life. Fractures of the spinal column in the elderly may result in a higher mortality rate [2,3,10,13]. Kyphoplasty in these patients may reduce pain significantly and, thus, increase their physical capability and quality of life [9,11,16].…”

Section: Discussionmentioning

confidence: 99%

Postoperative aseptic osteonecrosis in a case of kyphoplasty

et al. 2008

View full text Add to dashboard Cite

Aseptic osteonecrosis appears to be an infrequent adverse event after kyphoplasty which has not previously been reported. In the following, we present the case of a 73-year-old female who sustained a compression fracture of the first lumbar vertebra (L1) in a motor vehicle accident. The fracture was treated by kyphoplasty using PMMA cement. Three weeks after hospital discharge the patient was presented with increasing back pain. In imaging, dislocation of the PMMA cement could be shown combined with a total collapse of the L1 vertebra. The resulting significant kyphosis was first reduced by dorsal transpedicular (Th12-L2) internal fixation and stabilized by an anterior cage after total removal of the cement plomb and some remaining bone of the L1 vertebra. Bacterial as well as histological examination of the cement and bone led to the diagnosis of aseptic osteonecrosis. Different underlying events could be discussed. We think it most likely that the osteoporotic bone was unable to interface sufficiently with the PMMA cement and, therefore, disintegrated under loading. Furthermore, the volume of injected cement could have significantly compromised the blood supply within the bone.

show abstract

Section: Discussionmentioning

confidence: 99%

Postoperative aseptic osteonecrosis in a case of kyphoplasty

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Η οστεοπόρωση στην Ευρωπαϊκή Ένωση θεω ρείται μία από τις κυριότερες αιτίες αναπηρίας και θα νάτου σε προχωρημένες ηλικίες (Kado et al 1999, Ismail et al 1998. Οι οικονομικές επιπτώσεις για την ενδονοσοκομειακή και την εξωνοσοκομειακή φροντί δα ασθενών με οστεοπόρωση έχει υπολογιστεί ότι φτάνουν τα 36 δις € ανά έτος .…”

Section: εισαγωγηunclassified

Animal models of osteoporosis

Lelovas

2017

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

Osteoporosis is an important systemic disorder, affecting mainly Caucasian women, with a diverse and multifactorial aetiology. A large variety of animal species, such as rodents, rabbits, dogs, sheep and primates, have been used as animal models in osteoporosis research. Their use enhanced our understanding on the etiology of osteoporosis. Additionally, many therapeutic regimes have entered clinical practice after evaluation on animal models. Experimental protocols leading to bone loss include hormonal interventions (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy), immobilization, alcohol abuse osteoporosis and osteoporosis induced by food manipulation. Methods of bone mass evaluation, used on animal models, are biochemical markers, densitometry, magnetic resonance imaging, histomorphometry and bone mechanical testing.

show abstract

“…Kyphosis secondary to osteoporotic vertebral compression fractures is associated with a 2 to 3 times greater incidence of death due to pulmonary causes. 5,11,13,17 Although usual treatment of an osteoporotic vertebral compression fracture consists of bed rest, analgesics, and bracing, some fractures go on to progressive deformity and debilitating pain.…”

Section: Introductionmentioning

confidence: 99%