Vertebral fracture assessment-detected abdominal aortic calcification and cardiovascular disease in rheumatoid arthritis

Akheel, Mohammad; Lohan, Derek G.; Bergin, Diane; Mooney, Sarah; O’Donnell, Martin; Amin, Shreyasee; Coughlan, Robert J.; Carey, John J.

doi:10.1016/j.semarthrit.2013.09.007

Cited by 5 publications

(2 citation statements)

References 46 publications

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“…These images simultaneously capture the presence of abdominal aortic calcification (AAC) that can be assessed by an expert reader to produce an AAC24 score. AAC from these images has been shown to be associated with cardiovascular disease events in older individuals 14-18 and specific patient populations such as those with rheumatoid arthritis 19 . Previous studies using AAC assessed by high radiation exposure CT have found AAC is a marker of generalized coronary and extracoronary atherosclerosis burden 20, 21 , however no studies have reported the relationship using images captured from a DXA machine.…”

Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women

Lewis

Schousboe

Lim

et al. 2016

ATVB

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Objective Dual-energy X-ray bone absorptiometry (DXA) is a low-cost, minimal-radiation technique used to improve fracture prediction. DXA machines can also capture single-energy lateral spine images and abdominal aortic calcification (AAC) is commonly seen on these images. Approach and Results We investigated whether DXA-derived measures of AAC were related to an established test of generalized atherosclerosis in 892 elderly Caucasian women aged over 70 years with images captured during bone density testing in 1998/1999 and B-mode carotid ultrasound in 2001. AAC scores were calculated using a validated 24 point scale into low (AAC24 score, 0 or 1), moderate (AAC24 scores 2-5) and severe AAC (AAC24 scores >5) seen in 45%, 36% and 19% respectively. AAC24 scores were correlated with mean and maximum common carotid artery intimal medial thickness (r=0.12, P<0.001 and r=0.14, P<0.001). Compared to individuals with low AAC, those with moderate or severe calcification were more likely to have atherosclerotic plaque (adjusted prevalence ratio (PR) 1.35, 95%CI; 1.14-1.61, P<0.001 and PR 1.94 95%CI; 1.65-2.32, P<0.001 respectively) and moderate carotid stenosis (adjusted PR 2.22, 95%CI; 1.39-3.54, P=0.001 and 4.82 95%CI; 3.09-7.050, P<0.001). The addition of AAC24 scores to traditional risk factors improved identification of women with carotid atherosclerosis as quantified by C-statistic (+0.075, P<0.001), net reclassification (0.249, P<0.001) and integrated discrimination (0.065, P<0.001). Conclusions Abdominal aortic calcification identified on images from a DXA machine were strongly related to carotid ultrasound measures of atherosclerosis. This low-cost, minimal radiation technique used widely for osteoporosis screening is a promising marker of generalized extracoronary atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women

Lewis

Schousboe

Lim

et al. 2016

ATVB

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“…VFA scans may show other irregularities, such as aortic calcification presence. The degree of calcification may be quantified to deliver an important mark of prevailing cardiovascular disorder, which provides cardiovascular events future prediction 28 .…”

Section: Use Of Vfa In Clinical Practicementioning

confidence: 99%

Additional tools for the estimation of fracture risk using DXA method

Vako¹

2021

JRPMS

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As the world population grows, the life expectancy of the elderly will continue to grow. With the growing prevalence of various chronic diseases, the incidence of fragility fractures caused by osteoporosis is expected to further increase in the future. DXA is a simple, inexpensive and safe technique currently used for the diagnosis of osteoporosis, but numerous osteoporotic fractures also present in patients with osteopenia. Other techniques using the DXA technology also currently employed, such as the assessment of bone quality by analyzing bone microarchitecture with Trabecular Bone Score (TBS), or geometrical properties of the femur with Hip Structural Analysis (HSA) contribute to the prediction of fracture risk and bone strength, while Vertebral Fracture Assessment (VFA) serves in assessing prevalent vertebral fractures by replacing conventional X-ray.

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Abdominal aortic calcification on dual-energy X-ray absorptiometry: Methods of assessment and clinical significance

Schousboe

Lewis

Kiel

2017

Bone

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Vertebral fracture assessment-detected abdominal aortic calcification and cardiovascular disease in rheumatoid arthritis

Cited by 5 publications

References 46 publications

Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women

Abdominal Aortic Calcification Identified on Lateral Spine Images From Bone Densitometers Are a Marker of Generalized Atherosclerosis in Elderly Women

Additional tools for the estimation of fracture risk using DXA method

Abdominal aortic calcification on dual-energy X-ray absorptiometry: Methods of assessment and clinical significance

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