Vertebral endplate defects are associated with bone mineral density in lumbar degenerative disc disease

Li, Ruoyu; Zhang, Wei; Xu, Yafei; Ma, Lei; Li, Zhaohui; Yang, Dalong; Ding, Wenyuan

doi:10.1007/s00586-022-07329-1

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…For this investigation, 987 consecutive patients, who underwent spinal magnetic resonance imaging (MRI), X-ray examination of the lumbar spine and dual energy x-ray absorptiometry (DXA) examinations were selected for this study. The inclusion criteria were as follows: (1) DDD patients including lumbar intervertebral disc protrusion, degenerative lumbar spondylolisthesis, and degenerative lumbar spinal stenosis [ 17 , 18 ]. At least one of the aforementioned conditions were present for DDD diagnosis; (2) All MRI and DXA examinations were performed separately on the same machine, and the interval between MRI, X-ray and DXA examinations was < 15 days.…”

Section: Methodsmentioning

confidence: 99%

“…Okano I et al suggested that the endplate damage degree has a strong direct correlation with the regional volume BMD (vBMD), as evidenced by quantitative computed tomography (QCT) [ 16 ]. Li R et al reported that patients with DDD who had higher lumbar BMD tended to have higher rates of endplate damage [ 17 ]. In contrast, the study of Zhuang C et al revealed completely opposite results [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between lumbar endplate damage and bone mineral density in patients with degenerative disc disease

Huang,

Lu,

Shi

et al. 2023

BMC Musculoskelet Disord

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Background To explore the independent association between lumbar endplate damage and bone mineral density (BMD) in patients with degenerative disc disease (DDD). Methods This retrospective investigation was based out of a prospectively collected database from the Affiliated Kunshan Hospital of Jiangsu University. Data from 192 DDD patients, collected between December 2018 and January 2022, were chosen for the final analysis. The average total endplate score (TEPS) of lumbar(L) 1-L4 was assessed by magnetic resonance imaging (MRI), and represents the extent of endplate damage. Osteoporosis severity was assessed via the L1-L4 BMD evidenced by dual-energy x-ray absorptiometry (DXA). Other analyzed information included gender, age, body mass index (BMI), and osteophyte score (OSTS). Uni- and multivariate linear regression analyses were employed to evaluate the association between average TEPS and BMD of L1-L4. Moreover, the generalized additive model (GAM) was employed for non-linear association analysis. Results Upon gender, age, BMI, and OSTS adjustments, a strong independent inverse relationship was observed between average TEPS and BMD (β, -0.021; 95% CI, -0.035 to -0.007, P-value = 0.00449). In addition, the gender stratification analysis revealed a linear relationship in males, and a non-linear relationship in females. Specifically, there was a significantly stronger negative relationship between average TEPS and BMD in females, when the average TEPS was < 3.75 (β, -0.063; 95% CI, -0.114 to -0.013; P-value = 0.0157). However, at an average TEPS > 3.75, the relationship did not reach significance (β, 0.007; 95% CI, -0.012 to 0.027; P-value = 0.4592). Conclusions This study demonstrated the independent negative association between average TEPS and BMD values of L1-L4. Upon gender stratification, a linear relationship was observed in males, and a non-linear association in females. The findings reveal that patients with osteoporosis or endplate damage require more detailed examinations and treatment regimen.

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Section: Methodsmentioning

confidence: 99%