Vertebral Compression Fractures

Milby, Andrew H.; Ughwanogho, Ejovi; Hebela, Nader M.; Smith, Harvey E.

doi:10.1007/978-3-319-72228-3_11

Cited by 2 publications

(1 citation statement)

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“…Vertebral compression fractures (VCFs) occur by the collapse of a vertebral body segment onto itself, either due to trauma or more commonly due to osteoporosis. [1] VCFs that predominantly occur due to osteoporosis affect 30-50% of individuals over 50, resulting in an annual occurrence of 1.5 million VCFs and an annual cost of 750 million dollars. [2][3][4] Up to 75% of these fractures are found in the bone cements to act as a bone-void filler that stabilizes a fractured vertebra.…”

Section: Introductionmentioning

confidence: 99%

Azo polymerization of citrate‐based biomaterial‐ceramic composites at physiological temperatures

Huddleston

Duan

2022

Nano Select

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Vertebral compression fractures due to osteoporosis are commonly treated with bone cements based on the non-degradable, mechanically stiff poly(methyl methacrylate) (PMMA), which relies on peroxide-initiated polymerization to quickly set the cement at the cost of high exothermic temperatures. Recently, there has been interest in developing degradable, bone mechanic-matching alternatives that pursue physiologically induced polymerization to both augment the handling of the material before application and to reduce high localized temperatures that may lead to tissue damage. Herein, we report the development and material characterization of a thermoresponsive, degradable bone cement that utilizes the azo-based radical initiator 2-2ʹ-azobis (4-methoxy-2,4-dimethyl valeronitrile) (V70) and a liquid citrate-based biomaterial-ceramic composite of methacrylated poly(1,8 octamethylene citrate) (mPOC) and hydroxyapatite (HA) nanoparticles (mPOC-HA) that has improved handling and tissue compatibility characteristics. Our results show that: (a) these composites remain liquid until they are exposed to body temperature, which initiates polymerization to form a solid, tough material with desirable, modular compressive strengths comparable to trabecular bone; (b) the addition of HA decreases temperature generation below the threshold that leads to tissue necrosis; and (c) composites remain biocompatible in vitro and in vivo.

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Section: Introductionmentioning

confidence: 99%