Vertebral body defects treated with umbilical-cord mesenchymal stem cells combined with hydroxyapatite scaffolds: The first case report

Rahyussalim, Ahmad Jabir; Ivansyah, Muhammad Deryl; Nugroho, Ahmad; Wikanjaya, Rio; Canintika, Anissa Feby; Kurniawati, Tri

doi:10.1016/j.ijscr.2019.12.002

Cited by 4 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2017, the first patient suffering from an infected non-union right femoral shaft fracture with significant bone loss was successfully treated with a combination of allogeneic UC-MSCs, bone morphogenetic protein-2 (BMP-2), hydroxyapatite (HA), and mechanical stabilization using the Masquelet technique (Dilogo et al, 2017). Three years later, a case of vertebral defect was successfully treated with expanded UC-MSCs and HA (Rahyussalim et al, 2020).…”

Section: Perinatal Derivativesmentioning

confidence: 99%

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Bouland

Philippart

Dequanter

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Bone regeneration is a complex, well-orchestrated process based on the interactions between osteogenesis and angiogenesis, observed in both physiological and pathological situations. However, specific conditions (e.g., bone regeneration in large quantity, immunocompromised regenerative process) require additional support. Tissue engineering offers novel strategies. Bone regeneration requires a cell source, a matrix, growth factors and mechanical stimulation. Regenerative cells, endowed with proliferation and differentiation capacities, aim to recover, maintain, and improve bone functions. Vascularization is mandatory for bone formation, skeletal development, and different osseointegration processes. The latter delivers nutrients, growth factors, oxygen, minerals, etc. The development of mesenchymal stromal cells (MSCs) and endothelial progenitor cells (EPCs) cocultures has shown synergy between the two cell populations. The phenomena of osteogenesis and angiogenesis are intimately intertwined. Thus, cells of the endothelial line indirectly foster osteogenesis, and conversely, MSCs promote angiogenesis through different interaction mechanisms. In addition, various studies have highlighted the importance of the microenvironment via the release of extracellular vesicles (EVs). These EVs stimulate bone regeneration and angiogenesis. In this review, we describe (1) the phenomenon of bone regeneration by different sources of MSCs. We assess (2) the input of EPCs in coculture in bone regeneration and describe their contribution to the osteogenic potential of MSCs. We discuss (3) the interaction mechanisms between MSCs and EPCs in the context of osteogenesis: direct or indirect contact, production of growth factors, and the importance of the microenvironment via the release of EVs.

show abstract

Section: Perinatal Derivativesmentioning

confidence: 99%

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Bouland

Philippart

Dequanter

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…Biomaterial telah menjadi perbincangan hangat bagi para peneliti material sains. Biomaterial ini mampu membangkitkan berbagai potensi pada beberapa jaringan tubuh [1][2][3]. Berbagai biomaterial telah diteliti dan dikembangkan termasuk hidroksiapatit.…”

Section: Articles Alkimia Jurnal Ilmu Kimia Dan Terapan Pendahuluanunclassified

Sintesis Hidroksiapatit dari Tulang Ikan Patin melalui Metode Presipitasi

Asril¹,

Rahayuningsih²

2020

ALKIMIA

View full text Add to dashboard Cite

Tulang ikan patin telah berhasil disintesis menjadi hidroksiapatit melalui metode presipitasi. Tulang ikan Patin digunakan karena akan menghasilkan hidroksiapatit yang lebih biokompatibel dengan tulang. Model yang digunakan adalah percobaan laboratorium melalui metode presipitasi yang mensintesis tulang ikan patin yang telah dikalsinasi dengan asam nitrat, aquades, ammonium hidroksida dan diammonium hidrogen fosfat sehingga menghasilkan produk hidroksiapatit. Hasil FTIR menunjukkan bahwa terdapat gugus-gugus penyusun hidroksiapatit pada puncak puncaknya. XRD menunjukkan bahwa porduk yang dihasilkan memang benar hidroksiapatit karena sesuai dengan standar dari ICCS. Hasil dari SEM menunjukkan terdapat aglomerasi dari produk yang dihasilkan dikarenakan metode presipitasi itu sendiri.

show abstract

Finite element analysis of C1 – L5 spinal bone simulators made of various high elastic modulus polymer filaments

Nadhif

Irsyad

Kurniawati

et al. 2022

The 6TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, AND MEDICAL DEVICES: Proceedings of the 6t

View full text Add to dashboard Cite

Vertebral body defects treated with umbilical-cord mesenchymal stem cells combined with hydroxyapatite scaffolds: The first case report

Cited by 4 publications

References 30 publications

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Cross-Talk Between Mesenchymal Stromal Cells (MSCs) and Endothelial Progenitor Cells (EPCs) in Bone Regeneration

Sintesis Hidroksiapatit dari Tulang Ikan Patin melalui Metode Presipitasi

Finite element analysis of C1 – L5 spinal bone simulators made of various high elastic modulus polymer filaments

Contact Info

Product

Resources

About