Vertebral and Pulmonary Actinomycosis Mimicking Metastatic Lung Cancer

Fichte, Susanne; Brodhun, Michael; Göttinger, Sascha; Rosahl, Steffen K.; Klisch, Joachim; Gerlach, Rüdiger

doi:10.1055/s-0033-1342930

Cited by 7 publications

(4 citation statements)

References 15 publications

(19 reference statements)

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“…The lesions of bone metastases from LC are usually osteolytic with poor prognosis, and the prognosis of metastatic spinal cord compression of LC is even worse [2,9]. The imaging tests of metastatic LC include masses in the lobe with enlarged hilar or mediastinal lymph nodes combined with a collapsed vertebral body with spinal cord compression [10]. Here, we report a rare example of spinal cord compression resulting from soft tissue epidural MM of the thoracic spine.…”

Section: Discussionmentioning

confidence: 89%

Multiple Myeloma Rather Than Metastatic Lung Cancer: An Unexpected Cause of Spinal Cord Compression

Chen,

Yan,

Liu

et al. 2023

World J Oncol

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Spinal cord compression caused by cancer metastasis is a medical emergency that should be managed positively. Both multiple myeloma and lung cancer can lead to metastatic deposits in the spinal column to induce compression of the spinal cord. However, co-occurring multiple myeloma and lung cancer in a single patient causing spinal cord compression are rarely reported in the literature. We describe a case of a 61-year-old female with multiple myeloma and lung cancer whose radiologic characteristics of spinal cord compression mimicked those of metastatic lung cancer. Finally, the diagnosis was multiple myeloma. We showed the systematic imaging manifestations of metastatic multiple myeloma and discussed their therapeutic management.

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Section: Discussionmentioning

confidence: 89%

Multiple Myeloma Rather Than Metastatic Lung Cancer: An Unexpected Cause of Spinal Cord Compression

Chen,

Yan,

Liu

et al. 2023

World J Oncol

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“…Actinomycosis, also known as "the great masquerade," can present as systemic manifestations that mimic various types of malignancies in different parts of the body. For example, vertebral and pulmonary actinomycosis can resemble metastatic lung cancer, while ovarian, rectal, pelvic, and pancreatic actinomycosis may be mistaken for malignancies in their respective organs [12][13][14][15][16][17]. In the case of primary gastric actinomycosis, patients may experience symptoms suggestive of gastric outlet obstruction, leading to misdiagnosis as gastric cancer or lymphoma initially.…”

Section: Discussionmentioning

confidence: 99%

A Case of Pulmonary Actinomycosis With Concurrent Gastric Adenocarcinoma in an Older Adult

Zhang,

Liu,

Kang

et al. 2024

Cureus

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Actinomycosis is a chronic granulomatous disease that can affect various parts of the body, including the head and neck, lungs, abdominal and pelvic cavities, and wounds. It is caused by different actinomycetes like Actinomyces sherdii , Actinomyces glasii , Actinomyces cariosa , Actinomyces zurichensis , and Actinomyces europaea . Reported infections caused by actinomycetes include pulmonary actinomycosis, pelvic and abdominal infections, bone or artificial joint infections, endocarditis, complicated urinary tract infections, and soft tissue abscesses. The combination of pulmonary actinomycosis with gastric cancer is exceptionally rare in clinical practice, and the presence of actinomycetal infection alongside tumors in elderly patients poses significant challenges in treatment. This article presents the diagnosis and treatment process of an elderly patient with pulmonary actinomycosis and gastric adenocarcinoma.

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“… 40 , 41 Bony metastatic disease leads to vertebral collapse, causing spinal cord compression, which is a typical example of involvement of the central nervous system. 42 Invasion of the brachial plexus by thoracic tumours is a common example of involvement of the peripheral nervous system. 43 In addition, remote effects of cancer on the immune system activate inflammatory cascade, which would also exacerbate cancer metabolism and the injury of nerves further.…”

Section: General Overview Of Cancer-related Neuropathic Painmentioning

confidence: 99%

Contribution of immune cells to cancer-related neuropathic pain: An updated review

Pan

Lai

et al. 2023

Mol Pain

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Given that the incidence of cancer is dramatically increasing nowadays, cancer-related neuropathic pain including tumor-related and therapy-related pain gradually attracts more attention from researchers, which basically behaves as a metabolic-neuro-immune disorder with worse clinical outcomes and prognosis. Among various mechanisms of neuropathic pain, the common underlying one is the activation of inflammatory responses around the injured or affected nerve(s). Innate and adaptive immune reactions following nerve injury together contribute to the regulation of pain. On the other hand, the tumor immune microenvironment involving immune cells, as exemplified by lymphocytes, macrophages, neutrophils and dendritic cells, inflammatory mediators as well as tumor metastasis have added additional characteristics for studying the initiation and maintenance of cancer-related neuropathic pain. Of interest, these immune cells in tumor microenvironment exert potent functions in promoting neuropathic pain through different signaling pathways. To this end, this review mainly focuses on the contribution of different types of immune cells to cancer-related neuropathic pain, aims to provide a comprehensive summary of how these immune cells derived from the certain tumor microenvironment participate in the pathogenesis of neuropathic pain. Furthermore, the clarification of roles of various immune cells in different tumor immune microenvironments associated with certain cancers under neuropathic pain states constitutes innovative biology that takes the pain field in a different direction, and thereby provides more opportunities for novel approaches for the prevention and treatment of cancer-related neuropathic pain.

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Vertebral and Pulmonary Actinomycosis Mimicking Metastatic Lung Cancer

Abstract: Thoracic actinomycosis with spinal involvement is a rare disease. Therefore, diagnosis may be difficult. Surgical intervention, correct diagnosis, and specific long-term antibiotic treatment resulted in favorable outcome.

Cited by 7 publications

References 15 publications

Multiple Myeloma Rather Than Metastatic Lung Cancer: An Unexpected Cause of Spinal Cord Compression

Multiple Myeloma Rather Than Metastatic Lung Cancer: An Unexpected Cause of Spinal Cord Compression

A Case of Pulmonary Actinomycosis With Concurrent Gastric Adenocarcinoma in an Older Adult

Contribution of immune cells to cancer-related neuropathic pain: An updated review

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