Vertebra Cerrahisinde İntraoperatif Yüksek Doz Traneksamik Asit İnfüzyonu: Klinik Deneyimlerimiz

Abstract

We aimed to share our experiences on perioperative blood loss and the prevalence of side effects of high-dose tranexamic acid (TXA) used intraoperatively in vertebral surgeries. Material and Method: Thirty-four patients with the class of American Society of Anaesthesiology(ASA) I-III who underwent posterior spinal instrumentation and osteotomy at ≥5 vertebral levels were retrospectively analysed. TXA was administered intravenously from beginning to end of surgery at a loading dose of 50 mg/kg and a maintenance dose of 10 mg/kg/h. In addition to routine monitoring, minimal invasive cardiac output measurement was also used. Operative parameters, intraoperative-postoperative blood loss, mean volume of blood transfusion and fluids, hospitalization time, Hb, BUN, creatinine, Plt, INR levels, side effects and complications were recorded and evaluated. Results: Median value of fused spinal segments was 12 (7-13). Intraoperative blood loss was 1448.53±767.18 ml, 133.85±61.77 ml per fused spinal segment and 172.79±82.12 ml per hour during the operation. While intraoperative blood loss was significantly lower in patients undergoing primary surgery than in revision patients, there was no difference in terms of postoperative blood loss. It was directly correlated with the number of fused vertebrae, duration of surgery, age and ASA. Mean amount of red blood cell transfused was 1.5±1.29U. There were no significant complications or side effects such as thromboembolism, seizure or renal failure in our patients. Conclusion: Although appropriate dosages are not yet established, we think that a loading dose of 50 mg/kg TXA can be used safely in vertebral surgeries without causing significant side effects.