Abstract:Zusammenfassung.
Dale‐Laidlaws Methode wurde etwas modifiziert, wodurch eine bessere Ausbeute, und diese in kürzerer Zeit, gewonnen werden konnte.
Als erste Reinigung des Rohsekretins wurde ein Extraktionsverfahren mit 95 %‐igem Alkohol ausgearbeitet.
Es wurde gezeigt, dass das wirksame Prinzip sich zwischen Wasser und Chloroform verteilen kann und unter Umständen auch in Benzollösung geht. Diese Löslichkeit konnte mit Wahrscheinlichkeit auf das Vorhandensein von einer ausgeprägt wasserlöslichen lipoiden Sub… Show more
“…Already from 1912, attempts had been made in several laboratories to purify and isolate secretin from intestinal extracts ( 26 , 27 , 28 , 29 ). The goal was – as just mentioned – to have a pure and stable secretin preparation for physiological and clinical tests of exocrine pancreatic functions ( 30 ).…”
Section: The Cholecystokinin (Cck) Storymentioning
confidence: 99%
“… Figure 1 The amino sequence of porcine cholecystokinin-33 (CCK-33), the originally identified CCK-peptide (Mutt & Jorpes ( 39 )). The bioactive CCK-8 sequence ( 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ) is underlined. Only the amino acids in the encircled positions no.…”
Section: The Cholecystokinin (Cck) Storymentioning
The birth certificate for endocrinology was Bayliss’ and Starling’s demonstration in 1902 that regulation of bodily functions is not only neuronal, but due also to blood-borne messengers. Starling named these messengers hormones. Since then, transport via blood has defined hormones. This definition, however, may be too narrow. Thus, today we know that several peptide hormones not only are produced and released to blood from endocrine cells. They are released also from neurons, myocytes, immune cells, endothelial cells, spermatogenic cells, fat cells, etc. And they are often secreted in cell-specific molecular forms with more or less different spectra of activity. The present review depicts this development with the story about cholecystokinin, which was discovered in 1928 as a hormone and still in 1976 was conceived as a single blood-borne peptide. Todays’ multifaceted picture of cholecystokinin suggests that time may be ripe for expansion of the hormone concept to all messenger molecules, which activate their target cells – irrespective of their road to the target (endocrine, neurocrine, neuronal, paracrine, autocrine, etc.) and irrespective of their kind of activity as classical hormone; growth factor; neurotransmitter; adipokine; cytokine; myokine; or fertility factor.
“…Already from 1912, attempts had been made in several laboratories to purify and isolate secretin from intestinal extracts ( 26 , 27 , 28 , 29 ). The goal was – as just mentioned – to have a pure and stable secretin preparation for physiological and clinical tests of exocrine pancreatic functions ( 30 ).…”
Section: The Cholecystokinin (Cck) Storymentioning
confidence: 99%
“… Figure 1 The amino sequence of porcine cholecystokinin-33 (CCK-33), the originally identified CCK-peptide (Mutt & Jorpes ( 39 )). The bioactive CCK-8 sequence ( 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ) is underlined. Only the amino acids in the encircled positions no.…”
Section: The Cholecystokinin (Cck) Storymentioning
The birth certificate for endocrinology was Bayliss’ and Starling’s demonstration in 1902 that regulation of bodily functions is not only neuronal, but due also to blood-borne messengers. Starling named these messengers hormones. Since then, transport via blood has defined hormones. This definition, however, may be too narrow. Thus, today we know that several peptide hormones not only are produced and released to blood from endocrine cells. They are released also from neurons, myocytes, immune cells, endothelial cells, spermatogenic cells, fat cells, etc. And they are often secreted in cell-specific molecular forms with more or less different spectra of activity. The present review depicts this development with the story about cholecystokinin, which was discovered in 1928 as a hormone and still in 1976 was conceived as a single blood-borne peptide. Todays’ multifaceted picture of cholecystokinin suggests that time may be ripe for expansion of the hormone concept to all messenger molecules, which activate their target cells – irrespective of their road to the target (endocrine, neurocrine, neuronal, paracrine, autocrine, etc.) and irrespective of their kind of activity as classical hormone; growth factor; neurotransmitter; adipokine; cytokine; myokine; or fertility factor.
“…A historical and technical survey is given by iMutt (23) i n his thesis 1959. 'l'he first non-toxic secretin preparations with a high biological activity that found widespread clinical application (21) were produced by Hammersten, Jorpes and Agren (15) in the thirties. By the introduction of a new method for the preparation of secretin 1953 Jorpes and Mutt (16) succeeded in producing secretin preparations of the hitherto highest hiological activity (17,18,19).…”
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