Versuche zur Hemmung der Autoprothrombin C-Wirkung

Abstract

ZusammenfassungDie Autoprothrombin C-Wirkung wird durch die Thrombokinase-Hemmstoffe Ixodin, Argasin und Sojabohnen-Trypsin-Inhibitor gehemmt, während der Thrombinhemmstoff Hirudin ohne Einfluß auf die APC-Aktivität ist.

The Role of Proaccelerin in Human Blood Coagulation. Evidence that Proaccelerin Is Converted to a Prothrombin-converting Principle by Activated Stuart Factor: With Notes on the Anticoagulant Action of Soybean Trypsin Inhibitor, Protamine Sulfate, and Hexadimethrine Bromide*

“…The conclusions regarding the action of soybean trypsin inhibitor in coagulation differ somewhat from those of other investigators (38,39) since, at the concentrations tested, we were able to localize the anticoagulant effect to a specific stage of coagulation, the formation of the prothrombinconverting principle. Our studies localizing this inhibitor action at the interaction of activated Stuart factor and proaccelerin are consistent with the observations of other investigators (38)(39)(40)(41)(42)(43)(44) that, at the concentrations tested here, this inhibitor acts at a stage preceding the formation of thrombin.…”

Biochemistry of blood platelets. Interaction of activated factor X with platelets

“…The shape change which follows is probably due to slow conversion of platelet prothrombin into thrombin by Xa. Hirudin inhibits thrombin but not Xa when tested in coagulation assays (Markwardt et al, 1964). However, it prevented aggregation of platelets by X» as well as by thrombin.…”

“…Effect of Hirudin on Aggregation Induced by Activated Factor X. Hirudin is known to inhibit the action of thrombin in converting fibrinogen into fibrin (Markwardt, 1961).…”

Inventory of Coagulation Inhibitors from Animals Feeding on Blood

“…Sabbatani described the active principle which was named ixodin as an enzyme that destroys thrombin. Later the agent was characterized as an inhibitor of the first coagulation phase ( 6,7) and as a potent inhibitor of factor Xa (8). Substances with corresponding points of attack in the blood coagulation system were also found in Ixodes dammini (9), Dermaceter andersoni (10) and Boophilus microplus (11).…”

“…The factor from the latter tick, called argasin, was characterized as an antithromboplastic agent (18) with strong inhibitory action against factor Xa (8). It was later isolated (19,20) and named tick anticoagulant peptide (TAP).…”