Versuche zur Aufkl�rung der Beziehung zwischen Glucolysehemmung und Kaliumverlust bei der Fluoridvergiftung von Menschenerythrocyten

Lindemann, B.; Passow, Hermann

doi:10.1007/bf00362092

Cited by 11 publications

(4 citation statements)

References 12 publications

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“…If the initial change in osmotic fragility were normal but versity of Sheffield. the timing of sequential events were abnormal, as suggested by earlier observations at 24 and 48 hours of incubation (3), an alternate explanation would be needed.…”

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confidence: 81%

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Studies on the Osmotic Fragility of Incubated Normal and Abnormal Erythrocytes*

Haut¹,

Tudhope²,

Cartwright³

et al. 1962

J. Clin. Invest.

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The osmotic fragility of erythrocytes is known to undergo alterations when whole blood is incubated under aseptic conditions for 24 hours. The osmotic fragility of spherocytes increases considerably ( 1 ). Normal erythrocytes undergo a slight increase in fragility (2) and by contrast the osmotic fragility of leptocytes and certain other erythrocytes (3) is decreased. The sequence of events associated with this divergent change and the factors which influence it are the subjects of this study.Under certain circumstances the normal erythrocyte may behave as an osmometer (4). Though not implying "rupture" of the erythrocyte (5), osmotic lysis occurs when the red cell volume increases to a critical value (6, 7). In in vitro systems, the degree of osmotic lysis which may occur is affected by pH, temperature, and tonicity (8) of the surrounding medium. If these variables are held constant, then alterations in the osmotic fragility of the incubated erythrocytes would reflect changes in their milieu interne which result from metabolic activity during incubation.Abnormality of shape or volume of erythrocytes or both is presumed to alter their osmotic fragility by virtue of altering the span between the initial volume and the critical hemolytic volume of the cell (6, 7, 9). However, abnormal cell geometry does not, by this means, account for the apparent paradoxical response of the osmotic fragility of leptocytes to incubation. If the initial direction of change in the osmotic fragility of incubated leptocytes were abnormal, an abnormality of erythrocyte metabolism would be suggested. If the initial change in osmotic fragility were normal but

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confidence: 81%

“…Both of these events may be associated with the fall in the concentration of adenosine triphosphate which follows upon the cessation of glycolysis (23,24). Apparently the permeability of the red cell membrane is altered when glycolysis ceases (25).…”

Section: Methodsmentioning

confidence: 99%

Studies on the Osmotic Fragility of Incubated Normal and Abnormal Erythrocytes*

Haut¹,

Tudhope²,

Cartwright³

et al. 1962

J. Clin. Invest.

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“…Cell metabolism has been shown to play a role in K+ permeability in red cell membranes (21) and may play a mediating role in the increase K+ permeability of these cells. Inhibition of glycolysis or substrate deprivation appears necessary for the action of fluoride on passive K+ permeability (22,23). Gardos (24) on the other hand has demonstrated that the addition of calcium chelators (EDTA) or the removal of calcium from the system will prevent the fluoride-induced K+ permeability, independent of fluoride effects on metabolism or ATP levels.…”

Section: Methodsmentioning

confidence: 99%

Potassium permeability in β-thalassemia minor red blood cells

Gunn¹,

Silvers²,

Rosse³

1972

J. Clin. Invest.

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“…In a number of papers Passow et al deal with potassium loss from fluoride-treated human red cells (194,195,197,198,235). The effect appears to be complex.…”

Section: ) and Wilbrandtmentioning

confidence: 95%

Transport Through Biological Membranes

Wilbrandt¹

1963

Annu. Rev. Physiol.

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This review covers, essentially, material published in the years 1960 and 1961. For reasons of space, work on plant cells, physicochemical studies on inanimate membranes, and most of the work on electrophysiology (even if it touched transport problems) had to be excluded. A number of symposia were held dealing wholly or partly with transport problems (25,112,173,256, 282) and several surveys were published (43, 82, 242, 331, 333, 338a). Some reviews of more restricted scope will be mentioned below. A number of con tributions to the symposia mentioned (particularly 173) also have the charac ter of reviews.Developments of special interest, in the opinion of the reviewer, include the growing amount of valuable information gained from bacteria (especially from studies on permease systems for which mutants lacking enzymes or perm eases are especially favorable), the increasing evidence for the operation of carrier systems, the approach towards better understanding of the alkali cation transport based on the study of membrane ATPase, and the growing knowledge about the types of functional membrane polarity in transporting cells, mainly of epithelia. GENERAL ASPECTS OF MEMBRANE PASSAGEPorosity and experimental determination of pore sizes in cell membra1tes.A number of papers, mainly from Solomon's laboratory, deal with the deter mination of pore sizes in cell membranes [summaries: (288, 289)J, from meas urements of the osmotic pressure developed across a membrane permeable for a solute. From the "reflection coefficient" of Staverman (the ratio of the observed pressure to the theoretical osmotic pressure according to Van't Hoff's law) and from the molecular radius of the solute, the equivalent pore radius can be assessed by graphical methods. The equations used have been tested by Durbin (88) on collodium membranes. In the human red cell (110), measurements with nine solutes yielded an equivalent pore radius of 4.2 A, as compared to 3.5 A determined previously by means of the Pappenheimer Ussing method of comparing the rates of water movement under concentra tion and osmotic pressure gradients. In the resting axolemma of the squid axon (319, 320), a value of 4.2SA was found by Villegas & Barnola, as 1 The survey of literature pertaining to this review was concluded in December 1961 (occasional references are made to papers published in the first half of 1962). S Abbreviations used repeatedly in this review are: ADP (adenosine diphosphoric acid); ATP (adenosine triphosphoric acid); DNP (2,4-dinitrophenol). 601 Annu. Rev. Physiol. 1963.25:601-630. Downloaded from www.annualreviews.org Access provided by New York University -Bobst Library on 02/07/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

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Versuche zur Aufkl�rung der Beziehung zwischen Glucolysehemmung und Kaliumverlust bei der Fluoridvergiftung von Menschenerythrocyten

Cited by 11 publications

References 12 publications

Studies on the Osmotic Fragility of Incubated Normal and Abnormal Erythrocytes*

Studies on the Osmotic Fragility of Incubated Normal and Abnormal Erythrocytes*

Potassium permeability in β-thalassemia minor red blood cells

Transport Through Biological Membranes

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