Versuche, inoperable Carcinome mit Insulin zu behandeln

Silberstein, F.; Freud, J.; Révész, Tibor

doi:10.1007/bf02610147

Cited by 7 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While Brünings' experiments probably constitute the first clinical cohort study involving a detailed description of and focus on a KD, there exists one earlier report from 1927 by Fritz Silberstein and co-workers 66 involving 21 non-operable cancer patients who were also treated with insulin injections (partly into the tumor) and a concurrent high caloric, very low carbohydrate diet g. Again, beneficial effects of the insulin on the general condition of the patients were noted, and some cases responded with a local regression of their tumors.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Wilhelm Brünings' forgotten contribution to the metabolic treatment of cancer utilizing hypoglycemia and a very low carbohydrate (ketogenic) diet

Klement

2019

Journal of Traditional and Complementary Medicine

View full text Add to dashboard Cite

The growing interest in the alterations of tumor cell metabolism and their possible therapeutic exploitation also spurred new complementary and integrative approaches such as treating patients with a ketogenic diet (KD). KDs aim at inhibiting glycolytic tumor metabolism and growth, and have therefore been proposed as adjuncts not only to standard-of-care, but also to other therapies targeting tumor metabolism. Here I describe the life and forgotten work of one of the earliest researchers who realized the importance of altered tumor cell metabolism and its possible exploitation through metabolic modifications: Wilhelm Brünings. Brünings was a German natural scientist and physician famous for his innovative contributions to the fields of physiology and otorhinolaryngology. Based on the findings of Otto Warburg and his physiological reasoning he started to experiment with insulin administration and KDs in his patients with head and neck cancers, aiming to maximally lower blood glucose concentrations. He obtained encouraging short-term results, although most tumors became refractory to treatment after several weeks. His pioneering work is worth revisiting, especially for an international readership that may be unaware of his efforts, as hypoglycemic treatments, including the use of insulin injections and KDs, are currently being re-investigated as complementary and integrative cancer treatments.

show abstract

Section: Discussionmentioning

confidence: 99%

“…hThis meal consisted of 500 ml whipped cream and 2 eggs. A typical breakfast described by Silberstein et al 66 . would consist of 250 ml whipped cream and one egg.…”

mentioning

confidence: 99%