Versorgungsforschung mit Routinedaten in der Onkologie

Hoffmann, Falk; Glaeske, Gerd

doi:10.1007/s00063-010-1073-z

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…Formal clinical trials usually enroll highly selected patients and apply high and rigid standards of quality control. However, daily clinical practice is different and often, the excellent results of pace-making clinical trials are not fully reproducible in clinical reality [35]. Patterns of care analyses aim to unveil this gap between scientific trials and clinical reality and seek to open avenues to narrow the gap [36].…”

Section: Discussionmentioning

confidence: 99%

Seminoma Clinical Stage 1 - Patterns of Care in Germany

et al. 2016

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Introduction: International guidelines are ambivalent regarding the recommendations for the management of clinical stage 1 (CS1) seminoma. Patients and Methods: During 2008-2013, 1,050 patients with seminoma CS1 were prospectively registered with regard to assessing management modality (radiotherapy, carboplatin, surveillance). Associations with tumor size, rete testis invasion, age, year of diagnosis, type of institution, and geographic location were assessed. Results: Of the total number of patients, 49.3% received carboplatin 1 course, 8.5% carboplatin 2 courses, 35.9% surveillance, and 6.3% radiotherapy. In 2013, surveillance increased significantly to 57.9%. Treatment decisions were significantly associated with rete testis invasion and tumor size. Carboplatin was applied significantly more in office clinics than elsewhere. There is some regional variation regarding treatment preferences. Conclusions: The rising acceptance of surveillance mirrors international trends. The associations with prognostic factors demonstrate care givers to be compliant with contemporary guidelines. The association with the type of institution suggests non-oncological factors to be also relevant in decision making.

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Section: Discussionmentioning

confidence: 99%

Seminoma Clinical Stage 1 - Patterns of Care in Germany

et al. 2016

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“…Compared to other routinely collected data, the data used here come with a number of advantages. Compared to German claims data for example, our data are not selective regarding the insurance company and most importantly, they include information on clinical staging (Hoffmann and Glaeske 2010 ). Compared to the mandatory cancer registry data, OncoBox Research data has slightly higher completeness on clinical staging which is typically below 75% in breast cancer patients (Koch-Institut 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers

Sibert

Brucker

Wöckel

et al. 2022

J Cancer Res Clin Oncol

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Neoadjuvant chemotherapy (NACT) is frequently used in patients with early breast cancer. Randomized controlled trials have demonstrated similar survival after NACT or adjuvant chemotherapy (ACT). However, certain subtypes may benefit more when NACT contains regimes leading to high rates of pathologic complete response (pCR) rates. In this study we analyzed data using the OncoBox research from 94,638 patients treated in 55 breast cancer centers to describe the current clinical practice of and outcomes after NACT under routine conditions. These data were compared to patients treated with ACT. 40% of all patients received chemotherapy. The use of NACT increased over time from 5% in 2007 up to 17.3% in 2016. The proportion of patients receiving NACT varied by subtype. It was low in patients with HR-positive/HER2-negative breast cancer (5.8%). However, 31.8% of patients with triple-negative, 31.9% with HR-negative/HER2-positive, and 26.5% with HR-positive/HER2-positive breast cancer received NACT. The rates of pCR were higher in patients with HR-positive/HER2-positive, HR-negative/HER2-positive and triple-negative tumors (36, 53 and 38%) compared to HR-positive/HER2-negative tumors (12%). PCR was achieved more often in HER2-positive and triple-negative tumors over time.This is the largest study on use and effects of NACT in German breast cancer centers. It demonstrates the increased use of NACT based on recommendations in current clinical guidelines. An improvement of pCR was shown in particular in HER2-positive and triple-negative breast cancer, which is consistent with data from randomized controlled trails.

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“…Eine Ursache für die zunehmende Popularität dieser Sekundärdatenquelle ist, dass diese Routinedaten unter Alltagsbedingungen generiert werden und daher einzigartige Informationen über das tatsächliche Versorgungsgeschehen enthalten [1]. Sie lassen bundesweite Analysen über verschiedene Bevölkerungsgruppen und Krankheitsbilder zu.…”

Section: Möglichkeiten Und Limitationenunclassified

Einführung des neuen Tätigkeitsschlüssels und seine Anwendung in GKV-Routinedatenauswertungen

Damm

Lange

Zeidler

et al. 2012

Bundesgesundheitsbl.

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In recent years, claims data analyses have become of increasing importance in several scientific disciplines in Germany. In specific research projects, it can be necessary to refine and to standardize the results by socioeconomic data. Information about graduation, social status, and occupation are provided by the German job role code for all people insured by statutory health insurance. During recent years, the working scheme has changed and new professions have appeared. Therefore, there has been a discussion about actualization and modification of the job role code. Since December 2011, an actualized job role code with an extensive set of new information is available. In addition, a new classification of professions is available in Germany which was considered in the design of the new job role code. The aim of this overview is to describe the structure of the new job role code as well as to discuss possible uses and limitations.

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Versorgungsforschung mit Routinedaten in der Onkologie

Cited by 11 publications

References 28 publications

Seminoma Clinical Stage 1 - Patterns of Care in Germany

Seminoma Clinical Stage 1 - Patterns of Care in Germany

Current clinical practice and outcome of neoadjuvant chemotherapy for early breast cancer: analysis of individual data from 94,638 patients treated in 55 breast cancer centers

Einführung des neuen Tätigkeitsschlüssels und seine Anwendung in GKV-Routinedatenauswertungen

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