Versatile wet-chemical synthesis of non-agglomerated CaCO3 vaterite nanoparticles

Schüler, Timo; Tremel, Wolfgang

doi:10.1039/c0cc05717g

Cited by 41 publications

(42 citation statements)

References 22 publications

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“…23 Colloidally stable particles may have further utility as pH neutralizers in other biological conditions. 1,15,24 To determine vaterite’s feasibility for pH neutralization in vivo , we studied the size and stability of these particles in different solvents, using time-resolved dynamic light scattering (TR-DLS) for 30 minutes. The duration was selected based estimated antacid activity.…”

Section: Resultsmentioning

confidence: 99%

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Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

et al. 2016

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Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.

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Section: Resultsmentioning

confidence: 99%

“…Several attempts have been made to synthesize the meta-stable vaterite form of calcium carbonate, however these particles are too big (>few micrometers), 9–11 are not stable for an extended period of time, 12,13 and have low phase purity. 14,15 …”

Section: Introductionmentioning

confidence: 99%

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

et al. 2016

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“…16 Mahamid et al 15 described ACP to be a major component of the initial mineral phase of bone. 20,21 Because of their positively charged surface, they can be functionalized with carboxylate or phosphonate bearing ligands, and they have a moderate solubility that allows their dissolution and transformation to HCA. This was supported by the preparation of citrate-functionalized carbonateapatite nanoparticles that lead to a gradual and homogeneous release of Ca 2+ ions for the precipitation of nanocrystalline apatite.…”

Section: Introductionmentioning

confidence: 99%

Transformation of vaterite nanoparticles to hydroxycarbonate apatite in a hydrogel scaffold: relevance to bone formation

et al. 2015

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Biomimetic materials have been gaining increasing importance for use as bone biomaterials, because they may provide regenerative alternatives for the use of autologous tissues for bone regeneration. We demonstrate a promising alternative for the use of biomimetic materials based on a biodegradable PEG hydrogel loaded with vaterite nanoparticles as mineral storage. Vaterite, the least stable CaCO 3 polymorph, is stable enough to ensure the presence of a potential ion buffer for bone regeneration, but still has sufficient reactivity for the transformation from CaCO 3 to hydroxyapatite (HA). A combination of powder X-ray diffraction (PXRD), electron microscopy, and Fourier-transform infrared (FT-IR) and Raman spectroscopy showed the transformation of vaterite nanoparticles incorporated in a PEG-acetal-DMA hydrogel to hydroxycarbonate apatite (HCA) crystals upon incubation in simulated body fluid at human body temperature within several hours. The transformation in the PEG-acetal-DMA hydrogel scaffold in simulated body fluid or phosphate saline buffer proceeded significantly faster than for free vaterite. The vaterite-loaded hydrogels were free of endotoxin and did not exhibit an inflammatory effect on endothelial cells. These compounds may have prospects for future applications in the treatment of bone defects and bone degenerative diseases. † Electronic supplementary information (ESI) available: Fig. S1, quantitative phase analysis and determination of the crystallite size based on the XRD data after soaking vaterite nanoparticles in SBF at 37 1C for (a) 24 h (b) 48 h and (c) 72 h. See

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“…50 m 2 g À1 were prepared following the procedure reported in ref. 38 and their crystallinity was conrmed by X-ray powder diffraction (PXRD). The as-prepared vaterite nanoparticles (Ø # 50 nm, Fig.…”

Section: Resultsmentioning

confidence: 99%

Designed peptides for biomineral polymorph recognition: a case study for calcium carbonate

et al. 2014

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With their unique ability for substrate recognition and their sequence-specific self-assembly properties, peptides play an important role in controlling the mineralization of inorganic materials in natural systems and in controlling the assembly of soft materials into complex structures required for biological functions. Here we report the use of an engineered heptapeptide that can differentiate between the crystalline anhydrous polymorphs of calcium carbonate. This peptide contains the positively charged amino acid arginine as well as proline rather than the prototypical negatively charged aspartate or glutamate units. Its affinity to vaterite compared to aragonite was demonstrated by fluorescence microscopy using biotinylated peptides. Crystallization experiments in the presence of the vaterite-affine peptide afforded only vaterite, whereas a mutant peptide, where a proline residue was replaced by glycine, exclusively leads to the formation of calcite.

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Versatile wet-chemical synthesis of non-agglomerated CaCO3 vaterite nanoparticles

Abstract: Calcium carbonate (vaterite) nanoparticles of 20-60 nm size were obtained without stabilizing tensides by heating a dispersion of calcium bicarbonate (CaHCO(3)) in ethylene glycol for 30 minutes at 40 to 100 °C.

Cited by 41 publications

References 22 publications

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization

Transformation of vaterite nanoparticles to hydroxycarbonate apatite in a hydrogel scaffold: relevance to bone formation

Designed peptides for biomineral polymorph recognition: a case study for calcium carbonate

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