2019
DOI: 10.1016/j.toxicon.2018.11.298
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Versatile spider venom peptides and their medical and agricultural applications

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Cited by 70 publications
(57 citation statements)
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References 220 publications
(217 reference statements)
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“…Thus, new insecticides with novel modes of action are much sought after. Spiders are professional insect killers, and they are the most speciose venomous animal, and consequently their venoms have been intensively studied as a potential source of novel bioinsecticides [17,[217][218][219][220][221]. As a result, many insecticidal toxins have been isolated from spider venoms, including peptides, proteins and polyamines, but they mostly lack the necessary taxonomic selectivity to be useful as insecticides.…”
Section: Targeting Vectors Of Human Disease With Venom-derived Toxinsmentioning
confidence: 99%
“…Thus, new insecticides with novel modes of action are much sought after. Spiders are professional insect killers, and they are the most speciose venomous animal, and consequently their venoms have been intensively studied as a potential source of novel bioinsecticides [17,[217][218][219][220][221]. As a result, many insecticidal toxins have been isolated from spider venoms, including peptides, proteins and polyamines, but they mostly lack the necessary taxonomic selectivity to be useful as insecticides.…”
Section: Targeting Vectors Of Human Disease With Venom-derived Toxinsmentioning
confidence: 99%
“…Several blockbuster drugs have been derived from venom components (Holford et al, 2018), but they were also investigated as research tools, cosmetics, industrial enzymes or bioinsecticides (e.g. Duterte and Lewis, 2010;Pennington et al, 2018;Dongol et al, 2019;Saez and Herzig, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…The presence of the PSM is su cient to assume that the peptide has neurotoxical activity as it binds ion channels (4), which may give it pain-relief properties. Peptides like Huentoxin-XVI (Ornithoctonus huwena) and ProTx-II (Thrixopelma pruriens) interrupt nociception in various models, while peptides like Ph 1β and PnPP-19 from the venom of Phoneutria nigriventer are around 180 times more potent that ziconotide (11)(12)(13). Moreover, DBPs have potential in other pathologies like ischemic stroke, as shown by the peptide PcTx1 (Psalmopoeus cambridgei), in epilepsy, as shown by the peptide Hm3a (Heteroscrodra maculate), and in neurodegenerative diseases, as shown by the peptide PhKv (Phoneutria nigriventer) in Alzheimer's and Guangxitoxin-1E in Parkinson's models (12).…”
mentioning
confidence: 99%
“…Peptides like Huentoxin-XVI (Ornithoctonus huwena) and ProTx-II (Thrixopelma pruriens) interrupt nociception in various models, while peptides like Ph 1β and PnPP-19 from the venom of Phoneutria nigriventer are around 180 times more potent that ziconotide (11)(12)(13). Moreover, DBPs have potential in other pathologies like ischemic stroke, as shown by the peptide PcTx1 (Psalmopoeus cambridgei), in epilepsy, as shown by the peptide Hm3a (Heteroscrodra maculate), and in neurodegenerative diseases, as shown by the peptide PhKv (Phoneutria nigriventer) in Alzheimer's and Guangxitoxin-1E in Parkinson's models (12). As a notable exception for a DBP peptide, Gomesin from Acanthoscurria gomesiana shows activity against gram positive and gram negative bacteria, fungi, yeast, malaria and leishmanial, while retaining anti cancerous activity in a murine melanoma model (14).…”
mentioning
confidence: 99%
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