Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Dominici, Nadia; Keller, Urs; Vallery, Heike; Friedli, Lucia; Brand, Rubia van den; Starkey, Malcolm; Musienko, Pavel; Riener, Robert; Courtine, Grégoire

doi:10.1038/nm.2845

Cited by 100 publications

(114 citation statements)

References 25 publications

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“…Stepping capacities were recorded on a motorized treadmill belt set at a constant speed of 9 cm/s. Animals wore a custom-made jacket especially designed for either bipedal or quadrupedal locomotion (Dominici et al, 2012) that was connected to an automated, servo-controlled body-weight support system (Robomedica Inc). The optimal amount of body weight support was determined visually.…”

Section: Kinematic Kinetic and Electromyography Recordingsmentioning

confidence: 99%

“…To evaluate the characteristics underlying stepping for the different experimental conditions, we implemented a multi-step statistical procedure based on principal component analysis (Courtine et al, 2009;Musienko et al, 2011;Dominici et al, 2012). The various steps, methods, typical results, and interpretation of the analysis are detailed in Figs 2 and 3.…”

Section: Principal Component Analysismentioning

confidence: 99%

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Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Beauparlant

Brand

Barraud

et al. 2013

Brain

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109

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Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emergence of abnormal reflex responses. Here, we hypothesize that undirected compensatory plasticity within neural systems caudal to a severe spinal cord injury contributes to the development of neuronal dysfunction in the chronic stage of the injury. We evaluated alterations in functional, electrophysiological and neuromorphological properties of lumbosacral circuitries in adult rats with a staggered thoracic hemisection injury. In the chronic stage of the injury, rats exhibited significant neuronal dysfunction, which was characterized by co-activation of antagonistic muscles, exhaustion of locomotor muscle activity, and deterioration of electrochemically-enabled gait patterns. As observed in humans, neuronal dysfunction was associated with the emergence of abnormal, longlatency reflex responses in leg muscles. Analyses of circuit, fibre and synapse density in segments caudal to the spinal cord injury revealed an extensive, lamina-specific remodelling of neuronal networks in response to the interruption of supraspinal input. These plastic changes restored a near-normal level of synaptic input within denervated spinal segments in the chronic stage of injury. Syndromic analysis uncovered significant correlations between the development of neuronal dysfunction, emergence of abnormal reflexes, and anatomical remodelling of lumbosacral circuitries. Together, these results suggest that spinal neurons deprived of supraspinal input strive to re-establish their synaptic environment. However, this undirected compensatory plasticity forms aberrant neuronal circuits, which may engage inappropriate combinations of sensorimotor networks during gait execution.

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Section: Kinematic Kinetic and Electromyography Recordingsmentioning

confidence: 99%

Section: Principal Component Analysismentioning

confidence: 99%

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Beauparlant

Brand

Barraud

et al. 2013

Brain

Self Cite

109

View full text Add to dashboard Cite

show abstract

“…Thus, we should differentiate between controlled recovery and function replacement, and be aware of its results and limitations. Recent research by Dominici et al [15] and van den Brandt et al [16] on remodeling of cortical projections, and restoration of control over electrochemically enabled spinal cord structures may be very important in the aforementioned area.…”

Section: Discussionmentioning

confidence: 99%

The prospects of brain — computer interface applications in children

Mikołajewska

Mikołajewski

2014

Open Medicine

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AbstractThe restoring of motor functions in adults through brain-computer interface applications is widely studied in the contemporary literature. But there is a lack of similar analyses and research on the application of brain-computer interfaces in the neurorehabilitation of children. There is a need for expanded knowledge in the aforementioned area. This article aims at investigating the extent to which the available opportunities in the area of neurorehabilitation and neurological physiotherapy of children with severe neurological deficits using brain-computer interfaces are being applied, including our own concepts, research and observations.

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“…No doubt the area described requires further identification of threats. Recent research of van den Brandt et al on electrochemical neuroprostheses and robotic postural interfaces in rats [23,24] or the research of Voge and Stegemann on the use of carbon nanotubes in NPs [25] makes ethical considerations more difficult because of new aspects requiring very specialized knowledge and experience, e.g., in the area of nanomedicine.…”

Section: Discussionmentioning

confidence: 99%

Ethical considerations in the use of brain-computer interfaces

Mikołajewska

Mikołajewski²

2013

Open Medicine

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AbstractNervous system disorders are among the most severe disorders. Significant breakthroughs in contemporary clinical practice may provide brain-computer interfaces (BCIs) and neuroprostheses (NPs). The aim of this article is to investigate the extent to which the ethical considerations in the clinical application of brain-computer interfaces and associated threats are being identified. Ethical considerations and implications may significantly influence further development of BCIs and NPs. Moreover, there is significant public interest in supervising this development. Awareness of BCIs’ and NPs’ threats and limitations allow for wise planning and management in further clinical practice, especially in the area of long-term neurorehabilitation and care.

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Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Cited by 100 publications

References 25 publications

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

The prospects of brain — computer interface applications in children

Ethical considerations in the use of brain-computer interfaces

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