Versatile Protein Nanogels Prepared by In Situ Polymerization

Ye, Yanqi; Yu, Jicheng; Gu, Zhen

doi:10.1002/macp.201500296

Cited by 27 publications

(21 citation statements)

References 68 publications

(128 reference statements)

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“…Recent studies have demonstrated the disruption of nanogels by using cross-linking agents sensible to temperature, light, differences in pH, use of disulfide bond linkages and cleavage by glutathione (GSH) enzyme. Therefore, the active principle can reach intracellular targets after nanogels are endocytosed, promoting endolysosome escape and improving intracellular therapy [ 59 , 60 , 61 ].…”

Section: Polymeric Nanocarriers Against Intracellular Infections: mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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Polymeric nanocarriers (PNs) have demonstrated to be a promising alternative to treat intracellular infections. They have outstanding performance in delivering antimicrobials intracellularly to reach an adequate dose level and improve their therapeutic efficacy. PNs offer opportunities for preventing unwanted drug interactions and degradation before reaching the target cell of tissue and thus decreasing the development of resistance in microorganisms. The use of PNs has the potential to reduce the dose and adverse side effects, providing better efficiency and effectiveness of therapeutic regimens, especially in drugs having high toxicity, low solubility in the physiological environment and low bioavailability. This review provides an overview of nanoparticles made of different polymeric precursors and the main methodologies to nanofabricate platforms of tuned physicochemical and morphological properties and surface chemistry for controlled release of antimicrobials in the target. It highlights the versatility of these nanosystems and their challenges and opportunities to deliver antimicrobial drugs to treat intracellular infections and mentions nanotoxicology aspects and future outlooks.

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Section: Polymeric Nanocarriers Against Intracellular Infections: mentioning

confidence: 99%

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

2020

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“…Protein drugs can be used to directly replace the dysfunctional endogenous protein and are applicable to a variety of cancer treatments, vaccinations and therapies for genetic disorders [46–48]. Additionally, because of the specific functionality and structural hierarchy, therapeutic proteins mitigate the side-effects of interference with the biological system [49,50]. However, the intrinsic properties of the therapeutic protein also pose significant challenges for the full potential of its transdermal delivery [49,51,52].…”

Section: Types Of Delivered Proteinmentioning

confidence: 99%

Polymeric microneedles for transdermal protein delivery

Ye¹,

Yu²,

Wen³

et al. 2018

Advanced Drug Delivery Reviews

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267

169

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The intrinsic properties of therapeutic proteins generally present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing the stratum corneum and directly translocating protein drugs into the systematic circulation. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied to deliver drugs both locally and systemically in applications ranging from vaccination to diabetes and cancer therapy. This review surveys the current design and use of polymeric MNs for transdermal protein delivery. The clinical potential and future translation of MNs are also discussed.

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“…Moreover, after functionalization or conjugation of other molecules, the protein properties and functions might be altered. In recent years, encapsulation of proteins by in situ polymerization was developed as an alternative strategies for protein modification (Ye et al, 2016b ). The protein nanogels were obtained by incorporation of cross-linkers to protein surface and polymerization.…”

Section: Othersmentioning

confidence: 99%

Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics

et al. 2018

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Over the past decade, more interests have been aroused in engineering protein-based nanoformulations for cancer treatment. This excitement originates from the success of FDA approved Abraxane (Albumin-based paclitaxel nanoparticles) in 2005. The new generation of biocompatible endogenous protein-based nanoformulations is currently constructed through delivering cancer therapeutic and diagnostic agents simultaneously, as named potential theranostics. Protein nanoformulations are commonly incorporated with dyes, contrast agents, drug payloads or inorganic nanoclusters, serving as imaging-guided combinatorial cancer therapeutics. Employing the nature identity of proteins, the theranostics, escape the clearance by reticuloendothelial cells and have a long blood circulation time. The nanoscale sizet allows them to be penetrated deeply into tumor tissues. In addition, stimuli release and targeted molecules are incorporated to improve the delivery efficiency. The ongoing advancement of protein-based nanoformulations for cancer theranostics in recent 5 years is reviewed in this paper. Fine-designed nanoformulations based on albumin, ferritin, gelatin, and transferrin are highlighted from the literature. Finally, the current challenges are identified in translating protein-based nanoformulations from laboratory to clinical trials.

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Versatile Protein Nanogels Prepared by In Situ Polymerization

Cited by 27 publications

References 68 publications

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

Recent Advances in Polymeric Nanoparticle-Encapsulated Drugs against Intracellular Infections

Polymeric microneedles for transdermal protein delivery

Bio-Inspired Protein-Based Nanoformulations for Cancer Theranostics

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