Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

Pichot, Selma Leulmi; Bentouati, Sabrina; Ahmad, Saif; Sotiropoulos, Marios; Jena, R.; Cowburn, R. P.

doi:10.1039/d0ra00164c

Cited by 6 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DNA repair capacity). 4,5 Different types of materials have already been investigated for their radio-enhancement properties, for example gold, 9 platinum, 10 hafnium dioxide, 11 and magnetic microdiscs 12 (see Kuncic et al 4 for a comprehensive review). Among these, gold nanoparticles (AuNP) are a natural choice as radio-enhancers due to their high atomic number, X-ray absorption cross section and biocompatibility, and are therefore the most widely researched nanoparticles to date.…”

Section: Introductionmentioning

confidence: 99%

Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In recent years, non-standard nanomedical instruments and technologies, including physical methods of tumor elimination, have been developed [9,10]. The variety of magnetic nanoparticles has become a unique, novel, and effective tool.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors

Zamay

Luzan

et al. 2023

JFB

View full text Add to dashboard Cite

One of the promising novel methods for radical tumor resection at a single-cell level is magneto-mechanical microsurgery (MMM) with magnetic nano- or microdisks modified with cancer-recognizing molecules. A low-frequency alternating magnetic field (AMF) remotely drives and controls the procedure. Here, we present characterization and application of magnetic nanodisks (MNDs) as a surgical instrument (“smart nanoscalpel”) at a single-cell level. MNDs with a quasi-dipole three-layer structure (Au/Ni/Au) and DNA aptamer AS42 (AS42-MNDs) on the surface converted magnetic moment into mechanical and destroyed tumor cells. The effectiveness of MMM was analyzed on Ehrlich ascites carcinoma (EAC) cells in vitro and in vivo using sine and square-shaped AMF with frequencies from 1 to 50 Hz with 0.1 to 1 duty-cycle parameters. MMM with the “Nanoscalpel” in a sine-shaped 20 Hz AMF, a rectangular-shaped 10 Hz AMF, and a 0.5 duty cycle was the most effective. A sine-shaped field caused apoptosis, whereas a rectangular-shaped field caused necrosis. Four sessions of MMM with AS42-MNDs significantly reduced the number of cells in the tumor. In contrast, ascites tumors continued to grow in groups of mice and mice treated with MNDs with nonspecific oligonucleotide NO-MND. Thus, applying a “smart nanoscalpel” is practical for the microsurgery of malignant neoplasms.

show abstract

Magnetic Micro- and Nanodisks: A Bridge Between Thin Films and Nanoparticles

Laureti,

Varvaro,

Peddis

2024

Magnetic Nanoparticles

View full text Add to dashboard Cite

Magnetic micro- and nanodisks represent a peculiar class of systems that combines the benefits of both thin films and nanoparticles, thus representing a bridge between them. The progress in designing, fabricating, and manipulating micro- and nanodisk systems is continuously enhancing the ability to tailor their properties, opening new opportunities to use them in fundamental studies and to explore new frontiers in materials science, physics, and other related fields.

show abstract

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

Abstract: First study demonstrating the use of physically engineered magnetic particles that display two functionalities for cancer treatment.

Cited by 6 publications

References 31 publications

Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues

Uptake, distribution and radio-enhancement effects of gold nanoparticles in tumor microtissues

Magnetic Nanoscalpel for the Effective Treatment of Ascites Tumors

Magnetic Micro- and Nanodisks: A Bridge Between Thin Films and Nanoparticles

Contact Info

Product

Resources

About