Versatile Functions of Caveolin-1 in Aging-related Diseases

Nguyen, Kim Cuc Thi; Cho, Kyung A

doi:10.4068/cmj.2017.53.1.28

Cited by 25 publications

(23 citation statements)

References 117 publications

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“…CAV1 is a major component of the caveolae structure and a trans-membrane protein well-known to regulate numerous cellular processes such as cell growth and differentiation or endocytosis but also the stress-induced senescence (Zou et al, 2011 ; Nguyen and Cho, 2017 ). CAV1 is notably upregulated during replicative and premature senescence.…”

Section: Senescence In Oamentioning

confidence: 99%

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

et al. 2018

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Osteoarthritis is the most common musculoskeletal disease causing chronic disability in adults. Studying cartilage aging, chondrocyte senescence, inflammation, and autophagy mechanisms have identified promising targets and pathways with clinical translatability potential. In this review, we highlight the most recent mechanistic and therapeutic preclinical models of aging with particular relevance in the context of articular cartilage and OA. Evidence supporting the role of metabolism, nuclear receptors and transcription factors, cell senescence, and circadian rhythms in the development of musculoskeletal system degeneration assure further translational efforts. This information might be useful not only to propose hypothesis and advanced models to study the molecular mechanisms underlying joint degeneration, but also to translate our knowledge into novel disease-modifying therapies for OA.

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Section: Senescence In Oamentioning

confidence: 99%

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

et al. 2018

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“…Caveolin-1 is essential for the formation of caveolae which generally distributed in endothelial cells, smooth muscle cells, skeletal myoblasts, adipocytes, and broblasts [18]. Caveolin-1 modulates multiple cellular functions such as cell proliferation, cellular senescence, lipid metabolism, cholesterol tracking, and signal transduction [19,20]. In the brain, caveolin-1 is primarily expressed in endothelial cells, pericytes, and astroglial cells [21,22], and caveolin-1 can regulate neuronal signaling and promote dendritic growth [23].…”

Section: Discussionmentioning

confidence: 99%

Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway.

Huang

Zhong

et al. 2020

Preprint

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Background: Rosiglitazone (RSG) is a widely used antidiabetic drug which activates peroxisome proliferator-activated receptor-γ. Recent work have shown that RSG can up-regulate caveolin-1 levels and ameliorate both chronic and acute brain injury. However, whether rosiglitazone can ameliorate ischemic injury in the brain via a caveolin-1-dependent pathway remains unknown. Methods: Adult male sprague-dawley rats were randomly divided into sham operation group, model group, rosiglitazone group and rosiglitazone+daidzein group. The rat models of middle cerebral artery occlusion (MCAO) was established using the suture method, with ischemia for 2 hours and reperfusion for 22 hours. Neurological deficits were evaluated by the methods of Longa’s standard scoring. Cerebral infarction volume was observed by staining with 2, 3, 5-triphenyltetrazolium chloride. Evans blue content reflects BBB permeability. The expressions of caveolin-1, matrix metalloproteinase-9(MMP-9) and occludin were detected by immunofluorescent staining and western blot. Results: In this study, we found that the expression of caveolin-1 was increased in a rat model of stroke, and treatment with RSG significantly increased the levels of caveolin-1, reduced the release of MMP-9, and increased the expression of occludin. On the other hand, a caveolin-1 inhibitor daidzein canceled the protective roles of RSG in the MCAO model.Conclusions: These data unveil that RSG might protect blood-brain barrier integrity by down-regulating the levels of MMP-9 via a caveolin-1-dependent pathway.

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“…Caveolin-1 is essential for the formation of caveolae which generally distributed in endothelial cells, smooth muscle cells, skeletal myoblasts, adipocytes, and broblasts [18]. Caveolin-1 modulates multiple cellular functions such as cell proliferation, cellular senescence, lipid metabolism, cholesterol tracking, and signal transduction [19,20]. In the brain, caveolin-1 is primarily expressed in endothelial cells, pericytes, and astroglial cells, and caveolin-1 can regulate neuronal signaling and promote dendritic growth [23].…”

Section: Discussionmentioning

confidence: 99%

Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway

Huang

Zhong

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Rosiglitazone (RSG) is a widely used antidiabetic drug which activates peroxisome proliferator-activated receptor-γ. Recent work have shown that RSG can up-regulate caveolin-1 levels and ameliorate both chronic and acute brain injury. However, whether rosiglitazone can ameliorate ischemic injury in the brain via a caveolin-1-dependent pathway remains unknown. Methods Adult male sprague-dawley rats were randomly divided into sham operation group, model group, rosiglitazone group and rosiglitazone + daidzein group. The rat models of middle cerebral artery occlusion (MCAO) was established using the suture method, with ischemia for 2 hours and reperfusion for 22 hours. Neurological deficits were evaluated by the methods of Longa’s standard scoring. Cerebral infarction volume was observed by staining with 2, 3, 5-triphenyltetrazolium chloride. Evans blue content reflects BBB permeability. The expressions of caveolin-1, matrix metalloproteinase-9(MMP-9) and occludin were detected by immunofluorescent staining and western blot. Results In this study, we found that the expression of caveolin-1 was increased in a rat model of stroke, and treatment with RSG significantly increased the levels of caveolin-1, reduced the release of MMP-9, and increased the expression of occludin. On the other hand, a caveolin-1 inhibitor daidzein canceled the protective roles of RSG in the MCAO model. Conclusions These data unveil that RSG might protect blood-brain barrier integrity by down-regulating the levels of MMP-9 via a caveolin-1-dependent pathway.

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Versatile Functions of Caveolin-1 in Aging-related Diseases

Cited by 25 publications

References 117 publications

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway.

Rosiglitazone Protects Blood-Brain Barrier Integrity Following Ischemic Stroke by Reducing MMP-9 Expression Through a Caveolin-1-Dependent Pathway

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