Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics

Ma, Yana; Zhao, Jingjie; Cheng, Liangliang; Li, Cheng; Yan, Xiangji; Deng, Zhichao; Zhang, Yujie; Liang, Jie; Liu, Cui; Zhang, Mingzhen

doi:10.1016/j.carbon.2023.01.006

Cited by 30 publications

(13 citation statements)

References 55 publications

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“…[84][85][86] Considering the situation where there are still inherent defects of natural superoxide dismutase, superoxide dismutase-like nanozymes have potential to be promising antioxidants or anti-inflammatory drugs in biomedicine. [87][88][89] Noteworthily, these nanozymes are often found to exhibit multiple antioxidant enzyme-like activities with synergistic therapeutic effects. They are often used in conjunction with catalase activity to remove ROS and reduce oxidative stress for various antioxidant treatments, such as lung injury and other lung inflammation.…”

Section: Catalase-like Activitymentioning

confidence: 99%

Advances and perspectives of nanozymes in respiratory diseases

He¹,

Shi²,

Zheng³

et al. 2023

J. Mater. Chem. B

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Section: Catalase-like Activitymentioning

confidence: 99%

Advances and perspectives of nanozymes in respiratory diseases

He¹,

Shi²,

Zheng³

et al. 2023

J. Mater. Chem. B

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“…Excess ROS can lead to lipid peroxidation, protein oxidation, and DNA damage, so removing ROS is a top priority. [14] Inspired by biology, Zhu et al developed a novel ROS scavenging sutures for wound treatment by covering surgical sutures with galacylated acid (GA) -based nanoparticles (GANPs). The resulting GANPS-coated sutures can effectively promote wound closure by maintaining tension and reducing ROS levels around the wound.…”

Section: Introductionmentioning

confidence: 99%

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

et al. 2023

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Overexpression of classically activated macrophages (M1) subtypes and assessed reactive oxygen species (ROS) levels are often observed in patients with ulcerative colitis. At present, the treatment system of these two problems has yet to be established. Here, the chemotherapy drug curcumin (CCM) is decorated with Prussian blue analogs in a straightforward and cost‐saving manner. Modified CCM can be released in inflammatory tissue (acidic environment), eventually causing M1 macrophages to transform into M2 macrophages and inhibiting pro‐inflammatory factors. Co(III) and Fe(II) have abundant valence variations, and the lower REDOX potential in CCM‐CoFe PBA enables ROS clearance through multi‐nanomase activity. In addition, CCM‐CoFe PBA effectively alleviated the symptoms of UC mice induced by DSS and inhibited the progression of the disease. Therefore, the present material may be used as a new therapeutic agent for UC.

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“…Inflammatory bowel disease (IBD) is a chronic autoimmune disease that is characterized by relapsing intestinal inflammation. − In the past decade, IBD has emerged as a public health challenge worldwide, affecting more than 6.8 million people, especially in western countries . There are two main forms: ulcerative colitis (UC) and Crohn’s disease (CD). , Although they share many clinical features, they are considered as distinct conditions, as their inflammatory prone areas are completely different. Although the exact etiology of disease is undefined, some factors have been suggested to be critical, such as genetics, microbiome, environmental stress, , and immune disorder …”

Section: Introductionmentioning

confidence: 99%

“…4 There are two main forms: ulcerative colitis (UC) and Crohn's disease (CD). 5,6 Although they share many clinical features, 7 they are considered as distinct conditions, as their inflammatory prone areas are completely different. Although the exact etiology of disease is undefined, some factors have been suggested to be critical, such as genetics, 8 microbiome, 9 environmental stress, 10,11 and immune disorder.…”

Section: Introductionmentioning

confidence: 99%

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

Zhang

et al. 2023

Biomacromolecules

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The pathogenesis of inflammatory bowel diseases (IBDs) including ulcerative colitis (UC) and Crohn’s disease is extremely cloudy. Maintaining the level of remission lesions in colitis is the default treatment attitude at present. Epithelial barrier restoration is considered as the same important strategy as colonic targeted drug delivery in UC treatment. In this paper, we developed a multilayer natural polysaccharide microsphere (pectin/chitosan/alginate) with pH and enzyme dual sensitivity to reduce the loss of medication in the upper digestive tract and preferentially adhere to exposed epithelial cells in colonic tissues by electrostatic forces for efficiently targeted UC treatment. Olsalazine as an inflammatory drug was efficiently loaded in the chitosan layer and realized a colonic pH-responsive drug release. Furthermore, the multilayer microspheres exhibited excellent capability in suppressing harmful flora and a bio-adhesion effect to extend the duration of local medicine. In the in vivo anti-colitis study, the downregulated levels of pro-inflammatory factors and the increase of tight junction protein indicated the excellent anti-inflammation effect of the olsalazine-loaded microspheres. In summary, these results showed that the multilayer natural polysaccharide microspheres could be a powerful candidate in the targeted drug delivery system for UC therapy.

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Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics

Cited by 30 publications

References 55 publications

Advances and perspectives of nanozymes in respiratory diseases

Advances and perspectives of nanozymes in respiratory diseases

A Curcumin‐Modified Coordination Polymers with ROS Scavenging and Macrophage Phenotype Regulating Properties for Efficient Ulcerative Colitis Treatment

Orally Administrated Olsalazine-Loaded Multilayer Pectin/Chitosan/Alginate Composite Microspheres for Ulcerative Colitis Treatment

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