Versatile antibacterial surface with amphiphilic quaternized chitin-based derivatives for catheter associated infection prevention

NO released via both a Cu-MOF-based donor and surface-catalyzed generation enhances anticoagulation and antibacterial surface effects

“…Severe cases will result in device failure, increasing patient morbidity, mortality, and healthcare costs. [5][6][7][8] More seriously, the bacterial colonization and the formation of biofilms during catheter implantation lead to catheter-associated bacterial infections, which can cause severe complications. 9,10 Currently, to solve these problems, injections of anticoagulants and antibiotics are common clinical treatments.…”

Preparation and properties of antibacterial biomaterial PAA/TiO2/Ag

“…Synthetic organic antimicrobials mainly include the quaternary ammonium series, the biguanide series, and the imidazole series. Xie F et al prepared antibacterial surfaces based on seasonal β‐chitin derivative and seasonal chitosan derivatives, and the results showed that they possessed excellent antibacterial properties against Gram‐positive and Gram‐negative bacteria, and prevented bacterial adhesion 5 . Gryson L et al studied the in vitro anti‐biofilm activity of povidone iodine and polyhexamethylene biguanide, and stated that both of them showed strong anti‐biofilm activity against methicillin‐resistant Staphylococcus aureus and Pseudomonas aeruginosa 6 .…”

“…Xie F et al prepared antibacterial surfaces based on seasonal β-chitin derivative and seasonal chitosan derivatives, and the results showed that they possessed excellent antibacterial properties against Gram-positive and Gram-negative bacteria, and prevented bacterial adhesion. 5 Gryson L et al studied the in vitro anti-biofilm activity of povidone iodine and polyhexamethylene biguanide, and stated that both of them showed strong anti-biofilm activity against methicillinresistant Staphylococcus aureus and Pseudomonas aeruginosa. 6 Although the antimicrobial properties of synthetic organic antimicrobials are excellent, most of them contain some shortcomings such as toxicity, resistance and lack of biocompatibility.…”

Quaternary Ammonium Salt-Modified Isabgol (Psyllium) Scaffold as an Antibacterial Dressing for Improved Wound Healing

“…QACs have been useful in disinfectants, pharmaceutical, hygiene and healthcare products for their antimicrobial action, which has been mainly attributed to the electrostatic interaction between the positively charged quaternary nitrogen of QAC and negatively charged phospholipids in bacterial membranes. 2,3-Epoxypropyltrimethylammonium chloride (EPTMAC) is a QAC that has been used in various applications including antibacterial textiles [23,24], food packaging [25,26], and biological applications [27,28]. We have previously been successful in demonstrating the use of Isabgol in biomedical applications, especially for wound healing [21,22].…”