Verrucous Hyperplasia of the Great Toe: A Case and a Review of the Literature

Scheinfeld, Noah; Yu, Thomas; Liu, Jin

doi:10.1111/j.1524-4725.2004.30070.x

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Long-term changes with pin use include general thickening and discoloration of the distal tissues [16]. This condition can sometimes develop into verrucous hyperplasia in long-time pin users, which is a hyperplastic disease of warty papules (10,(14)(15)17).…”

Section: Introductionmentioning

confidence: 99%

Comparison of interface pressures with pin and suction suspension systems

Beil¹,

Street²

2004

JRRD

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A common mode of limb suspension for transtibial amputees is the pin liner/shuttle lock system. Despite its popularity, some clinicians question its use because of observed daily and chronic changes to the residual limb. For this study, we measured limb interface pressures during ambulation with pin and suction suspension systems. No pressure differences were seen between the modes of suspension during stance phase. However, during swing phase, pin suspension maintained an average occlusive compressive pressure of 6.7 kPa on the proximal tissues, as compared to the subocclusive pressure of 1.1 kPa with suction suspension. Simultaneously, pin suspension elevated the peak magnitude of suction to -39.5 kPa at the distal residual limb, compared to -26.1 kPa with suction suspension. During swing phase, the pin liner squeezes proximally while creating a large suction distally on the residual limb and is the likely cause of daily and chronic skin changes observed in pin users.

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Section: Introductionmentioning

confidence: 99%

Comparison of interface pressures with pin and suction suspension systems

Beil¹,

Street²

2004

JRRD

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“…[1] The lesion also often presents as coalescent warty papules at amputated sites. [4] Histopathologically, these lesions exhibit verrucous projections, which are noted as two main types, the sharp (21%) and the blunt (79%). The sharp variety is seen as long, narrow, and predominantly orthokeratotic epithelium while the blunt variety shows broad, short, and mostly parakeratotic epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…This entity was first described by Shear and Pindborg in 1980 and was originally called oral florid papillomatosis. [3] Buccal mucosa is the most common site (57.89%) followed by the tongue, gingiva, and alveolar mucosa [4] seen to occur with a common age predilection being the fourth decade. [5] Although the name itself suggests the diagnosis, these lesions often require microscopic examination to confirm the diagnosis.…”

Section: Introductionmentioning

confidence: 99%

A case report of a recurring verrucous hyperplasia: Revisit a recurrence

Markose¹,

Sruthi²,

Balamanikandasrinivasan

et al. 2022

JADE

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Verrucous lesions are diagnostically challenging entities that are known to mimic a variety of potentially malignant as well as malignant disorders both clinically and histologically. Therefore, it would be wise not to make decisions based on clinical findings alone. Thorough clinical examination coupled with detailed history and histopathological correlation is required which is strongly suggested to render appropriate diagnosis. A case report of recurrent verrucous hyperplasia is presented in this article emphasizing the aforementioned.

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Viral Carcinogenesis in Skin Cancer

Molho‐Pessach¹,

Lotem

2007

Environmental Factors in Skin Diseases

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The skin is an organ in which direct contact with viruses, solar UV irradiation and increased susceptibility to immune suppression gather to support viral tumorigenesis. Viruses transform keratinocytes by activation of cancer-promoting genes. Viral proteins may directly act as oncogenes that drive cells to proliferate or generate inflammatory responses and cause regeneration of injured cells that eventually lead to malignant transformation. Accelerated viral carcinogenesis is observed in the immune-deficient host. Decreased T-cell reactivity and lower number of antigen-presenting cells in the skin assist in viral escape and emergence of skin tumors. Three pathogenic human viruses associated with skin neoplasms are described: human papilloma virus (HPV), Kaposi's sarcoma (KS)-associated herpesvirus and human T-cell leukemia virus type 1. HPV was linked to squamous cell carcinoma (SCC) of the skin after its role in SCC of the cervix has been discovered. In the rare autosomal recessive epidermodysplasia verruciformis, an increased susceptibility to specific HPV strains initially results in widespread wart infection and later in life in the development of SCC over the sun-exposed skin. The role of HPV in nonmelanoma skin cancer of immune competent hosts is more difficult to prove. The discovery of human herpesvirus 8 as the causative pathogen of KS was made following the AIDS epidemic, and its role in all clinical variants of this tumor was confirmed. KS-associated herpesvirus exerts its tumorigenic effect through a wide repertoire of genes that regulate angiogenesis, inflammation, and cell cycle. Human T-cell leukemia virus type 1 causes adult T-cell leukemia and is often associated with skin eruptions that share common features with cutaneous T-cell lymphoma. In summary, studies of oncogenic viruses shed light on molecular mechanisms leading to tumor formation and aid in recognition of new pathways of carcinogenesis.

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Verrucous Hyperplasia of the Great Toe: A Case and a Review of the Literature

Abstract: Verrucous hyperplasia occurs should not be confused with verrucous carcinoma or warts. Moreover, because it recurs after removal, surgery is not indicated; rather, compression therapy is indicated.

Cited by 3 publications

References 16 publications

Comparison of interface pressures with pin and suction suspension systems

Comparison of interface pressures with pin and suction suspension systems

A case report of a recurring verrucous hyperplasia: Revisit a recurrence

Viral Carcinogenesis in Skin Cancer

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