Verrucous cutaneous sarcoidosis

Smith, Harvey R.; Black, Martin M.

doi:10.1046/j.1365-2230.2000.00583.x

Cited by 17 publications

(12 citation statements)

References 3 publications

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“…A third case was treated with 40 mg daily tapered to 10 mg daily with decrease in the extent of lesions 4 . In yet another case, shaving a verrucous nodule flat in combination with hydroxychloroquine at 200 mg twice daily resulted in resolution without recurrence 5 . Our patient’s co‐morbidities limited the use of high‐dose systemic steroids, although low‐dose prednisone stopped disease progression.…”

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confidence: 75%

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Cutaneous sarcoidosis manifesting as extensive verrucous plaques

Koch¹,

Mahoney²,

Pariser³

2010

Int J Dermatology

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confidence: 75%

“…Four out of five cases occurred in young African‐American men 1–4 . The fifth case occurred in a 34‐year‐old African‐American woman 5 . In these cases, verrucous sarcoidosis occurred either alone or in conjunction with other clinical variants including papules, plaques, ulcerative papules or atrophic plaques.…”

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confidence: 98%

Cutaneous sarcoidosis manifesting as extensive verrucous plaques

Koch¹,

Mahoney²,

Pariser³

2010

Int J Dermatology

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“…11 Clinically, these may manifest as maculopapules, nodules, plaques, subcutaneous nodules, infiltrative scars, and lupus pernio. [1][2][3][4][5][6][7][8][9] Review of a report of 54 black South Africans with cutaneous manifestations of sarcoidosis and systemic disease revealed one verrucous appearing lesion. 22 Verrucous cutaneous sarcoidosis was first described by Irgang in 1950, and subsequently, only rare cases have been reported in the literature (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9] Because cutaneous sarcoidosis can exhibit many different morphologies, cutaneous sarcoidosis is known as one of the "great imitators" in dermatology. Infiltration with noncaseating granulomas is the hallmark of the disease, and it may result in various clinical manifestations.…”

Section: Introductionmentioning

confidence: 99%

Verrucous Cutaneous Sarcoidosis

Stockman

Rosenberg²,

Bengana

et al. 2013

The American Journal of Dermatopathology

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Sarcoidosis is a multisystem disorder of unknown origin, characterized by the accumulation of lymphocytes and mononuclear histiocytes inducing the formation of noncaseating "naked" epithelioid granulomas. The lungs, lymphatic system, and skin are most often affected, but sarcoidosis may affect any organ. Cutaneous involvement of sarcoidosis is often the sentinel sign of the disease, with the skin sometimes being exclusively affected. We present a case of a 54-year-old African American woman with long-standing history of pulmonary sarcoidosis that presented with multiple verrucous cutaneous lesions on the upper and lower extremities mimicking carcinoma. The initial cutaneous biopsy was superficial in nature, and the pathologist raised the consideration of a possible keratoacanthoma. A deeper skin shave biopsy was performed, and the histopathology showed verrucous pseudoepitheliomatous epidermal hyperplasia with scattered noncaseating granulomas in the superficial dermis. Stains (acid-fast bacillus, Periodic acid-Schiff, and Gomori-Grocott methenamine silver stains) were negative for microorganisms. Given the clinical setting and histomorphology of the cutaneous lesions, the diagnosis of verrucous sarcoidosis was rendered. Verrucous sarcoidosis is a rare cutaneous manifestation of sarcoidosis that could be easily misdiagnosed if it is not appropriately biopsied. This hinders the precise evaluation of the histological specimen, overall clinical picture, and administration of appropriate therapy.

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“…Atrophy as well as hyperkeratosis and verruciform hyperplasia of the epidermis are rarely found [67,68].…”

Section: Histopathology Of Cutaneous Sarcoidosismentioning

confidence: 99%

Sarcoidosis and molecular mimicry—important etiopathogenetic aspects: current state and future directions

Tchernev

Ananiev

Cardoso

et al. 2012

Wien Klin Wochenschr

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Sarcoidosis is a disease of uncertainty in terms of its cause, presentation, and clinical course. The disease has a worldwide distribution and affects all ages, races, and both sex. Sarcoidosis of the skin may have an extremely heterogeneous clinical presentation, so that the definitions of 'great imitator' and 'clinical chameleon' have long been used. The factors that influence clinical picture and severity of the disease are probably linked to the etiopathogenesis of sarcoidosis, which continues to be shrouded in mystery. The current state of the art on the pathogenesis of sarcoidosis is that it is an immunological response in a genetically susceptible individual to an as-yet undefined antigenic stimulus. How exposure occurs in genetically predisposed patients is not completely clear, but the most likely explanation is that these agents or antigens are either inhaled into the lungs or enter through contact with the skin, as these are the common target organs that are constantly in contact with the environment. An autoimmune etiology of sarcoidosis could possibly occur through a process of molecular mimicry of infectious or other environmental antigens to host antigens. This could lead to a cross-mediated immune response and induction of autoimmune disease. This molecular mimicry may probably be responsible for the heterogeneous clinical presentations of the disease. Several investigations and studies have provided valuable evidence on the etiopathogenesis of sarcoidosis, which may lead to the future development of targeted and innovative treatment strategies. Nevertheless, we are still a long way from unravelling the underlying cause of this mysterious disease.

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Verrucous cutaneous sarcoidosis

Cited by 17 publications

References 3 publications

Cutaneous sarcoidosis manifesting as extensive verrucous plaques

Cutaneous sarcoidosis manifesting as extensive verrucous plaques

Verrucous Cutaneous Sarcoidosis

Sarcoidosis and molecular mimicry—important etiopathogenetic aspects: current state and future directions

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