Verrucous Carcinoma of the Temporal Bone and Maxillary Antrum: Two Unusual Presentations of a Rare Tumor

Abstract

Verrucous carcinoma (VC) is a low-grade variant of squamous cell carcinoma. The involvement of the temporal bone and maxillary antrum is very rare. Patients and Methods: The clinicopathologic features of 2 such tumors are reported, and the pertinent literature is reviewed. Results: In the 2 patients, the diagnostic procedure was complicated due to initial inconclusive histology. Both were treated with concomitant radiochemotherapy. They were free of disease for 5.8 and 11 years after diagnosis. An additional 15 cases of VC of the temporal bone and 10 cases of maxillary antrum tumors have been reported in the literature. In 10 patients, multiple biopsies were required, and in 7 patients, a definitive histological diagnosis was not obtained before surgery. The disease reappeared in 8 out of 15 patients treated solely with surgery. Only 2 of them were salvaged by reoperation. Radiochemotherapy only (without any surgery) was successfully used in 4 patients. Conclusions: VC of the temporal bone or maxillary antrum is an extremely rare tumor. For reliable histological diagnosis, multiple biopsies of deep and ample tissue samples are mandatory. Surgery is a mainstay of therapy; however, radiochemotherapy also represents a viable treatment option with curative potential.

An individual drug-therapy and genetic testing report of temporal bone verrucous carcinoma

“…Based on a combination of the survey works of Strojan et al9 and Miller et al,10 all reported cases are summarized in Table 1.…”

“…Four cycles of chemotherapy administered as prolonged intravenous infusions of vinblastine, methotrexate, and bleomycin were applied, and this case died of bronchitis9 11 years later. After the treatment of the antimicrotubule drug vinblastine, the patient got a better prognosis.…”

Otolaryngology and the American Presidency: A Medical Legacy

“…Verrucous carcinoma of the maxillary sinus is an uncommon disease, and only 10 such cases have been reported in the literature to date [18] . Verrucous carcinoma was not described by Ackermann until 1948, and, despite its highly malignant clinical appearance, these tumors are deceptively benign histologically and cytologically [19] .…”