Verrucous Carcinoma of the Skin

Koch, Horst; Kowatsch, E.; Hödl, S; Smola, M. G.; Radl, Roman; Hofmann, Thiemo; Scharnagl, E.

doi:10.1097/00042728-200408000-00011

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Both recurrences occurred within 1 year after surgery, which is largely consistent with the findings of Koch et al (11) Studies have shown that SCC tumors with a diameter greater than 2 cm have a threefold increase in their metastatic rate (23). When the tumor invasion depth is greater than 6 mm, the metastasis rate is as high as 16% (32,33). However, the sites of our two recurrent patients were located in the foot and hand, and the tumor size and depth of infiltration were not significantly unusual.…”

Section: Discussionsupporting

confidence: 86%

Cutaneous verrucous carcinoma: A clinicopathological study of 21 cases with long-term clinical follow-up

Jia

et al. 2022

Front. Oncol.

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BackgroundCutaneous verrucous carcinoma (CVC) is a rare variant of squamous cell carcinoma and sometimes shares similar clinical and histopathological features with other verrucous lesions.MethodsWe performed a retrospective study of 21 patients diagnosed with CVC between 2012 and 2022 by reviewing clinical and histopathological data. We also compared the clinicopathological features of patients with CVC, giant condyloma acuminatum (GCA), and pseudoepitheliomatous hyperplasia (PEH). We obtained follow-up data by reviewing medical records and telephone interviews.ResultsThe average age of patients with CVC was 63.6 years, with a male predominance. The location of disease is mostly found in the foot, followed by the lower legs. Histologically, CVC is characterized by an exo-endophytic growth pattern with severe keratinization and a blunted rete ridge with pushing margins. Clinical features including exudation and crusting, induration, irregular borders, and warty surface, as well as pathological features including growth pattern, koilocytotic cells, depth and morphologic features of acanthosis, severe keratinization, and degree of dermal inflammation, were significant in distinguishing cutaneous CVC, GCA, and PEH.ConclusionIdentification of the clinicopathological features is essential to distinguish CVC from its mimics and to make an early diagnosis. Because of the potential for recurrence and metastasis, CVC requires aggressive treatment.

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Section: Discussionsupporting

confidence: 86%

Cutaneous verrucous carcinoma: A clinicopathological study of 21 cases with long-term clinical follow-up

Jia

et al. 2022

Front. Oncol.

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Surgical treatment of verrucous carcinoma: a review

Fawaz

Vieira

Decker

et al. 2022

Journal of Dermatological Treatment

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Гигантская Веррукозная Карцинома Кожи Нижних Конечностей

Лукьянов¹,

Киселев²

2020

Дерматовенерология Косметология

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Мы представляем клинический случай симметричной локализации верифицированной гигантской веррукозной карциномы кожи нижних конечностей у пациента с периферическим раком средней доли правого легкого в анамнезе.В настоящее время веррукозная карцинома рассматривается как клинико-патологический вариант сквамозно-клеточной карциномы (SCC). В разное время данная нозология была известна как опухоль Акермана (Ackerman’s tumor), опухоль Бушке – Левенштейна (Buschke – Lowenstein tumor), папилломатоз полости рта (Florid oral papillomatosis), подошвенная веррукозная карцинома (Epithelioma cuniculatum), Carcinoma cuniculatum, карциноидный папилломатоз Готтрона (Cutis papillomatosis carcinoides Gottron). Очевидная клиническая доброкачественность процесса может приводить в некоторых случаях к длительному периоду ошибочной диагностики; лимфатические узлы, как правило, поздно реагируют на него, даже при условии разрушения тканей носа, нижней челюсти, полового члена, нижних конечностей. Морфологически этот вариант SCC имеет признаки бородавчатого или веррукозного строения; для тех патологов, которые не знакомы с клиническим диагнозом, его относительно мягкие гистологические признаки часто больше указывают на verruca vulgaris, или псевдоэпителиоматозную гиперплазию, чем на плоскоклеточный рак. Вместе с тем при распространении процесса на подлежащие ткани его можно ошибочно гистологически принимать за доброкачественные опухоли придатков кожи или даже за эпидермоидную кисту. Лечение веррукозной SCC представляет собой сложную задачу из-за ожидаемых рецидивов, а также потенциальной анапластической трансформации после радиотерапии. We present a clinical case of symmetric localization of verified giant verrucous carcinoma of the skin of the lower extremities in a patient with a history of peripheral cancer of the middle lobe of the right lung.Currently, verrucous carcinoma is considered as a clinical and pathological variant of squamous cell carcinoma (SCC). At various times, this nosology was known as Ackerman’s tumor, Buschke – Lowenstein tumor, Florid oral papillomatosis, plantar verrucous carcinoma (Epithelioma cuniculatum), Carcinoma cuniculatum Cutis papillomatosis carcinoides Gottron). The obviousclinical benign quality of the process can lead in some cases to a long period of misdiagnosis; lymph nodes, as a rule, react late to it, even if the tissues of the nose, lower jaw, penis, and lower extremities are destroyed. Morphologically, this SCC variant has features of a warty or verrucous structure; for those pathologists unfamiliar with the clinical diagnosis, its relatively mild histologic features are often more indicative of verruca vulgaris or pseudoepitheliomatous hyperplasia than squamous cell carcinoma. At the same time, when the process spreads to the underlying tissues, it can be mistakenly histologically mistaken for benign tumors of the appendages of the skin or even for an epidermoid cyst. Treatment of verrucous SCC is challenging due to the anticipated recurrence as well as the potential anaplastic transformation following radiation therapy.

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Verrucous Carcinoma of the Skin

Cited by 4 publications

References 15 publications

Cutaneous verrucous carcinoma: A clinicopathological study of 21 cases with long-term clinical follow-up

Cutaneous verrucous carcinoma: A clinicopathological study of 21 cases with long-term clinical follow-up

Surgical treatment of verrucous carcinoma: a review

Гигантская Веррукозная Карцинома Кожи Нижних Конечностей

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