Verrucous Carcinoma of the Penis Completely Cured with Shaving and Intralesional Interferon

Fuente, Enrique Gómez de la; Suarez, Edwin; Sebastian, F. Vanaclocha; Rodríguez-Peralto, José L.; Diez, L. Iglesias

doi:10.1159/000018352

Cited by 16 publications

(3 citation statements)

References 7 publications

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“…346 Intra-aortic infusion chemotherapy with methotrexate has also been used. 347 A surgical approach is usually preferred, as it shows excellent treatment outcomes 348 and allows thorough histologic sampling and search for focal SCC.…”

Section: Verrucous Carcinomamentioning

confidence: 99%

Penile cancer

Micali

Nasca

Innocenzi

et al. 2006

Journal of the American Academy of Dermatology

116

118

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Section: Verrucous Carcinomamentioning

confidence: 99%

Penile cancer

Micali

Nasca

Innocenzi

et al. 2006

Journal of the American Academy of Dermatology

116

118

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“…The surgical margins were 2 cm in cases of partial penectomy and 0.3-1 cm in cases of local excision (Table 2) [5,6]. In contrast, some studies have emphasized the good clinical results of local excision because of the favorable clinical behavior of PVC [5,6,11,15,17,31,32,37,39,40,43,[45][46][47].…”

Section: Resultsmentioning

confidence: 99%

Optimal treatment for penile verrucous carcinoma: a systematic literature review

Han

Kim

et al. 2021

BMC Urol

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Background Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Methods: To identify the up-to-date general biological behavior, diagnosis, and treatment trends, we searched PubMed using the keyword “penile verrucous carcinoma” without restrictions on publication date. Results: Current treatments for penile verrucous carcinoma include wide surgical excision, seldom preventive lymphadenectomy, and conservative chemotherapy without surgery or local excision with safe margins. Despite the advent of partial penectomy to minimally impact function and aesthetics, affected patients experience psychosexual problems. Local excision can be used to save the penile shaft and glans penis without preventive lymphadenectomy or adjuvant therapy and can achieve good clinical prognosis with rare recurrence. Conclusions: To preserve the functional and cosmetic aspects, we recommend local excision, especially for tumors measuring < 3 cm and classified as stage T1 according to the 2016 tumor node metastasis clinical and pathological classification for penile cancer.

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“…However, the overall experience with multimodality therapy in penile carcinoma is limited to a small series with inconclusive results, and this area deserves therefore further exploration 75 . Finally, interferon, either administered systemically 103 or intralesionally in combination with surgical shaving, 104 may represent an option in relapsing VC. However, no reliable cure rates are available from these mostly anecdotally reported treatment modalities.…”

Section: Treatmentmentioning

confidence: 99%

Invasive Penile Carcinoma: A Review

Micali¹,

Nasca²,

Innocenzi³

et al. 2004

Dermatol Surg

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Although there are no current guidelines for the treatment of penile carcinoma, surgical ablation probably represents the best option, as conservative treatments still deserve cautious evaluation because of the relatively small number of treated patients and the lack of good-quality comparative data. Regarding indications for lymph nodal dissection in patients showing no inguinal node enlargement, sentinel node mapping with targeted lymph node dissection is recommended for those with deeply invasive, high-grade tumors, whereas a watchful waiting may be advised for those with superficially invasive, low-grade tumors.

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Verrucous Carcinoma of the Penis Completely Cured with Shaving and Intralesional Interferon

Cited by 16 publications

References 7 publications

Penile cancer

Penile cancer

Optimal treatment for penile verrucous carcinoma: a systematic literature review

Invasive Penile Carcinoma: A Review

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