Verrucous Carcinoma of the Face

Nguyen, Khoa Quoc; Mcmarlin, Stacy L.

doi:10.1001/archderm.1984.01650390105024

Cited by 23 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it appears most frequently on the plantar surface of the foot, anogenital area, and mouth. CVC is uncommon and has been found to occur on the face, maxillary antrum, and buttocks ( 2 – 4 ). Factors induced by chemical carcinogens, trauma, chronic irritability, and human papillomavirus are a few of the causes that have been linked to the development of CVC ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Crafting a prognostic nomogram for the overall survival rate of cutaneous verrucous carcinoma using the surveillance, epidemiology, and end results database

Chong

Huang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundThe aim of this study was to establish and verify a predictive nomogram for patients with cutaneous verrucous carcinoma (CVC) who will eventually survive and to determine the accuracy of the nomogram relative to the conventional American Joint Committee on Cancer (AJCC) staging system.MethodsAssessments were performed on 1125 patients with CVC between 2004 and 2015, and the results of those examinations were recorded in the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided at a ratio of 7:3 into the training (n = 787) and validation (n = 338) cohorts. Predictors were identified using stepwise regression analysis in the COX regression model for create a nomogram to predict overall survival of CVC patients at 3-, 5-, and 8-years post-diagnosis. We compared the performance of our model with that of the AJCC prognosis model using several evaluation metrics, including C-index, NRI, IDI, AUC, calibration plots, and DCAs.ResultsMultivariate risk factors including sex, age at diagnosis, marital status, AJCC stage, radiation status, and surgery status were employed to determine the overall survival (OS) rate (P<0.05). The C-index nomogram performed better than the AJCC staging system variable for both the training (0.737 versus 0.582) and validation cohorts (0.735 versus 0.573), which AUC (> 0.7) revealed that the nomogram exhibited significant discriminative ability. The statistically significant NRI and IDI values at 3-, 5-, and 8-year predictions for overall survival (OS) in the validation cohort (55.72%, 63.71%, and 78.23%, respectively and 13.65%, 20.52%, and 23.73%, respectively) demonstrate that the established nomogram outperforms the AJCC staging system (P < 0.01) in predicting OS for patients with cutaneous verrucous carcinoma (CVC). The calibration plots indicate good performance of the nomogram, while decision curve analyses (DCAs) show that the predictive model could have a favorable clinical impact.ConclusionThis study constructed and validated a nomogram for predicting the prognosis of patients with CVC in the SEER database and assessed it using several variables. This nomogram model can assist clinical staff in making more-accurate predictions than the AJCC staging method about the 3-, 5-, and 8-year OS probabilities of patients with CVC.

show abstract

Section: Introductionmentioning

confidence: 99%

Crafting a prognostic nomogram for the overall survival rate of cutaneous verrucous carcinoma using the surveillance, epidemiology, and end results database

Chong

Huang

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…A 61‐year‐old man presented with a large erythematous verrucous plaque encompassing the left upper eyelid, medial canthus, malar eminence, and left lower eyelid resulting in cicatricial ectropion (Figure A). He had the lesion surgically excised elsewhere twice in the past, and after repeat biopsy, the lesion was confirmed as a verrucous carcinoma, which may rarely involve the eyelids . After consideration of treatment options that included radiation therapy, he elected to undergo Mohs micrographic surgery, which after five stages, yielded an extensive (67 × 82 mm) residual periorbital defect that included a full‐thickness lower eyelid and canalicular defect (Figure B).…”

mentioning

confidence: 99%