Verrucous carcinoma associated with sacral bone destruction: An immunohistologic study on local invasion

名美子, 瀬津; 健治, 浅越; 香津恵, 原; 次郎, 荒田; 啓氏, 岩月

doi:10.5227/skincancer.18.174

Cited by 1 publication

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“…A significant increase in 15-HETE was detected in monocytes from patients with psoriatic arthritis (Wójcik et al, 2019). Epidermal expression of ALOX15B has been detected in normal human skin, as well as keratinocytes grown in culture (Shappell et al, 2001a;Setsu et al, 2006). Treatment of normal human epidermal keratinocytes and the keratinocyte cell line HaCaT with interferon-γ (IFNγ) (Setsu et al, 2006) or tumor necrosis factor-α (TNFα) in normal human epidermal keratinocytes (Banno et al, 2004) induced ALOX15B expression, indicating immune cell infiltration and inflammation may both induce epidermal ALOX15B in inflammatory skin diseases along with macrophage ALOX15B expression aiding in the production of oxylipins.…”

Section: Alox15b In Inflammatory Skin Diseasesmentioning

confidence: 99%

Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology

2022

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As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and linoleic acid (LA) to their corresponding fatty acid hydroperoxides. Distinctive to ALOX15B, fatty acid oxygenation occurs with positional specificity, catalyzed by the non-heme iron containing active site, and in addition to free PUFAs, membrane-esterified fatty acids serve as substrates for ALOX15B. Like other LOX enzymes, ALOX15B is linked to the formation of specialized pro-resolving lipid mediators (SPMs), and altered expression is apparent in various inflammatory diseases such as asthma, psoriasis, and atherosclerosis. In primary human macrophages, ALOX15B expression is associated with cellular cholesterol homeostasis and is induced by hypoxia. Like in inflammation, the role of ALOX15B in cancer is inconclusive. In prostate and breast carcinomas, ALOX15B is attributed a tumor-suppressive role, whereas in colorectal cancer, ALOX15B expression is associated with a poorer prognosis. As the biological function of ALOX15B remains an open question, this review aims to provide a comprehensive overview of the current state of research related to ALOX15B.

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