Verrucous Carcinoma Arising in Ulcerative Lichen Planus of the Soles

Mayron, Richard; Grimwood, Ronald E.; Siegle, Ronald J.; Camisa, Charles

doi:10.1111/j.1524-4725.1988.tb01150.x

Cited by 44 publications

(22 citation statements)

References 27 publications

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“…The risk of esophageal cancer, pancreatic cancer, and gallbladder cancer may be increased by inflammatory diseases, such as esophagitis, Barrett's metaplasia, and chronic pancreatitis (16,29). Possible associations were also found in Marjolin's ulcer and skin carcinoma (16), asbestos and mesothelioma (16), silica, cigarette smoke, and bronchial cancer (16), chronic asthma and lung cancer (30)(31)(32), sarcoidosis and lung, skin, and liver cancer (33), ulcerative lichen planus and verrucous carcinoma (34,35), foreskin inflammation/phimosis and penile cancer (36), and pelvic inflammatory disease or ovarian epithelial inflammation and ovarian cancer (16,37). Chronic prostatitis, resulting from either persistent bacteria infection or noninfective stimuli, was associated with prostate cancer (38).…”

Section: Inflammation and Cancer: Evidence From Epidemiology And Clinmentioning

confidence: 90%

Inflammation, a Key Event in Cancer Development

Ouyang

Huang

2006

Molecular Cancer Research

927

753

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Several recent studies have identified nuclear factor-KB as a key modulator in driving inflammation to cancers. Besides this transcription factor, essential in regulating inflammation and cancer development, an inflammatory microenvironment inhabiting various inflammatory cells and a network of signaling molecules are also indispensable for the malignant progression of transformed cells, which is attributed to the mutagenic predisposition of persistent infection-fighting agents at sites of chronic inflammation. As a subverted host response to inflammation-induced tumors, the inflammatory cells and regulators may facilitate angiogenesis and promote the growth, invasion, and metastasis of tumor cells. Thus far, research regarding inflammation-associated cancer development has focused on cytokines and chemokines as well as their downstream targets in linking inflammation and cancer. Moreover, other proteins with extensive roles in inflammation and cancer, such as signal transducers and activators of transcription, Nrf2, and nuclear factor of activated T cells, are also proposed to be promising targets for future studies. The elucidation of their specific effects and interactions will accelerate the development of novel therapeutic interventions against cancer development triggered by inflammation.

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Section: Inflammation and Cancer: Evidence From Epidemiology And Clinmentioning

confidence: 90%

Inflammation, a Key Event in Cancer Development

Ouyang

Huang

2006

Molecular Cancer Research

927

753

View full text Add to dashboard Cite

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“…2 On the other hand, less than 30 cases of carcinoma developing in cutaneous lichen planus have been reported, [3][4][5][6] 62% being hypertrophic lichen planus 3 and a lower proportion chronic ulcerative lesions. 3,7,8 However, only four cases of verrucous carcinoma associated with lichen planus have been reported in the literature, one oral and three cutaneous. 6,[8][9][10] Verrucous carcinoma is a low-grade, well-differentiated carcinomatous process displaying a marked tendency to compress and displace deeper tissues by downward growth rather than infiltrate them and having very low metastatic capability.…”

Section: Discussionmentioning

confidence: 99%

“…3,7,8 However, only four cases of verrucous carcinoma associated with lichen planus have been reported in the literature, one oral and three cutaneous. 6,[8][9][10] Verrucous carcinoma is a low-grade, well-differentiated carcinomatous process displaying a marked tendency to compress and displace deeper tissues by downward growth rather than infiltrate them and having very low metastatic capability. It usually originates in one of three locations, namely the oral cavity, genitalia or soles of the feet, but may occur anywhere on the skin.…”

Section: Discussionmentioning

confidence: 99%

Verrucous carcinoma in association with hypertrophic lichen planus

Castaño¹,

López‐Ríos

Álvarez-Fernández³

et al. 1997

Clinical and Experimental Dermatology

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Neoplastic transformation of lichen planus is a rare event. However, squamous cell carcinoma may develop in 0.3%-3% of patients with the oral form of the disease. On the other hand, less than 30 cases arising in cutaneous lichen planus have been reported, and only four cases of verrucous carcinoma in association with either form, one with an oral lesion and three with cutaneous lesions (one hypertrophic and one ulcerative). This report describes the unusual progression of a hypertrophic lichen planus plaque of the right leg to a verrucous carcinoma in a 40-year-old woman.

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“…One of the earliest descriptions of this phenomenon is that of Marjolin 122 in 1828 describing a relatively uncommon ulcerative condition associated with a thermal injury (Marjolin ulcer) in which malignant transformation occurs within a chronic inflammatory focus. 123 A similar association of SCC development with inflammatory disorders in nonhealing wounds has been described for lupus erythematosus, leg ulcerations, osteomyelitis, 124,125 perineal inflammatory disease, 125,126 ulcerative lichen planus 127 and epidermolysis bullosa of different etiology. 128Y130 More so, even areas of healed wounds with an established scar tissue are more susceptible to SCC and BCC development.…”

Section: Clinical Evidence Linking Inflammation and Skin Cancermentioning

confidence: 52%

“…136 In light of this, anti-inflammatory agents might indeed open a new and promising avenue in cancer prevention. 127 Perineal inflammatory disease SCC 125,126 Leg ulceration SCC 124 Severe thermal injury Marjolin ulcer (SCC)…”

Section: Discussionmentioning

confidence: 99%

Inflammation and Skin Cancer

Hensler

Mueller²

2013

The Cancer Journal

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Inflammation and the inflammatory infiltrate essentially contribute to tumor development and progression. For skin cancer, the observation that tumors arise in sites of chronic irritation and inflammation dates back to 1828 and has stimulated a whole field of research. Numerous animal models such as models of UV-induced or chemically induced skin carcinogenesis but also trangenic models support the role of a deregulated inflammation in the development of skin cancer. These models have greatly contributed to our understanding of the multistage process of carcinogenesis and have given important insights in the differences between physiological inflammation in a healing wound and the functional contribution of the deregulated tumor-associated inflammation to skin cancer growth and progression. Data from these models are supported by epidemiological studies that emphasize a connection of inflammatory conditions with the development of melanoma and epithelial skin cancer and give first indications for a beneficial effect of anti-inflammatory treatments in reducing the risk for skin cancer. Consequently, anti-inflammatory drugs might represent a highly interesting approach in the prevention and treatment of skin cancers.

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Verrucous Carcinoma Arising in Ulcerative Lichen Planus of the Soles

Cited by 44 publications

References 27 publications

Inflammation, a Key Event in Cancer Development

Inflammation, a Key Event in Cancer Development

Verrucous carcinoma in association with hypertrophic lichen planus

Inflammation and Skin Cancer

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