Verrucous carcinoma: a retrospective diagnosis in three historic patients

Teymoortash, Afshin; Silver, Carl E.; Rinaldo, Alessandra; Cardesa, Antonio; Folz, Benedikt J.; Ferlito, Alfio

doi:10.1007/s00405-013-2803-7

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…Very tactful, he was kind and caring with his patients and was good at comforting them [1]. Hans Pichler died on February 3 1949 in Vienna [12] (Figure 1).…”

Section: Hans Pichler (1877-1949)mentioning

confidence: 99%

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Treatment of Sigmund Freud?s Maxillary Jawbone Cancer by Hans Pichler and Varaztad Kazanjian (1856-1939)

Riaud¹

2014

Trauma Treat

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Passing through Europe for congresses in London and Paris in 1931, Kazanjian initially refused. Brunswick consequently asked for Princess Maria of Greece's help and she agreed. Kazanjian finally accepted and made a detour through Vienna on July 31 and August 1. He saw the philosopher on those two days at Pichler's dental office. On August 3, Freud wrote in his diary: "Something unbelievable happened! Within a day and a half, the magician made a prosthesis which is less intrusive and heavy than all the others and with which I can chew, talk and smoke like before [3]. With his own hands, he made three prostheses in Pichler's laboratory with the supplies that Princess Maria had sent him. Freud knew that Kazanjian could hardly help him more [5]. At a later date, Kazanjian said to one of his colleagues that there was little hope of the prosthesis being successful. Kaznajian left Vienna on August 29. On August 30 1931, Freud wrote: "The magician left yesterday. I do not feel as great as before but I can speak more easily. It will be difficult to do any more for me [3].

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“…Very tactful, he was kind and caring with his patients and was good at comforting them [1]. Hans Pichler died on February 3 1949 in Vienna [12] (Figure 1).…”

Section: Hans Pichler (1877-1949)mentioning

confidence: 99%

“…He was professor of Oral Surgery at Harvard Medical School in 1922 and professor of plastic surgery at Harvard Medical School in 1941. He was appointed professor emeritus of plastic surgery at the Harvard Medical School in 1947 [3,12] (Figure 2).…”

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confidence: 99%

Treatment of Sigmund Freud?s Maxillary Jawbone Cancer by Hans Pichler and Varaztad Kazanjian (1856-1939)

Riaud¹

2014

Trauma Treat

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“…Since Freud was a habitual cocaine user we hypothesized that his condition could be attributed to the necrotizing effect of cocaine abuse. Other authors have theorized that Freud actually suffered from verrucous squamous cell carcinoma [4], a clinico-pathological entity that was first recognized a few years after Freud's death [5]. Indeed, considering the historical accounts reviewed in both works, a diagnosis of verrucous squamous cell carcinoma can be reasonably taken into account.…”

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confidence: 99%

“…However, we do not share the absolute confidence in this hypothesis shown by its advocates in their comment to our communication as we are, likewise, not unconditionally convinced about our theory. Indeed, both diagnoses have been proposed posthumously without having access to the histopathological specimens and solely based on historical accounts [1,4]. Available data do not provide conclusive evidence in favor of neither verrucous carcinoma nor cocaine-induced lesion [1,4].…”

mentioning

confidence: 99%

“…Indeed, both diagnoses have been proposed posthumously without having access to the histopathological specimens and solely based on historical accounts [1,4]. Available data do not provide conclusive evidence in favor of neither verrucous carcinoma nor cocaine-induced lesion [1,4]. It can be reasonably affirmed that in the absence of further conclusive evidence, such as histopathological revision of surgical specimens, both theories deserve to be taken into consideration.…”

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Response to: Oral cancer of Sigmund Freud

Trimarchi

Bertazzoni

Bussi

2019

Eur Arch Otorhinolaryngol

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HPV-Related Head and Neck Squamous Cell Carcinomas

Marszałek

Szylberg

2016

HPV Infection in Head and Neck Cancer

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Since more than 5 years, it becomes evident that there is a new group of patients with squamous cell carcinomas of the head and neck area, namely human papillomavirus (HPV)-related (caused) tumors. As clinical statistics indicate, those patients have better prognosis, even despite more advanced stage compared to those with HPV-negative tumors. In fact, as a surrogate of HPV infection for clinical studies, an immunohistochemical expression of p16 protein is used. In the following chapter, the spectrum of squamous cell carcinomas variants with indication of the percentage cases with proved HPV infection will be presented.

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Verrucous carcinoma: a retrospective diagnosis in three historic patients

Cited by 10 publications

References 8 publications

Treatment of Sigmund Freud?s Maxillary Jawbone Cancer by Hans Pichler and Varaztad Kazanjian (1856-1939)

Treatment of Sigmund Freud?s Maxillary Jawbone Cancer by Hans Pichler and Varaztad Kazanjian (1856-1939)

Response to: Oral cancer of Sigmund Freud

HPV-Related Head and Neck Squamous Cell Carcinomas

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