Verrucous candidiasis of the lip: A harbinger of squamous cell carcinoma

Wang, Jake X.; Yu, Sherry H.; Hall, Rebecca R.; McNiff, Jennifer M.; Leffell, David J.; Kibbi, Nour

doi:10.1016/j.jdcr.2021.08.015

Cited by 1 publication

(2 citation statements)

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“…Progression of verrucous candidiasis of lip to SCC after 12 months of follow-up. A case report [33] Potential Carcinogenic Mechanisms of C. albicans…”

Section: Skin Cancermentioning

confidence: 99%

“…Although many studies associate Candida with oral, esophageal, gastric, and colorectal cancer, as described previously, studies researching the association between skin cancer and a Candida infection or skin colonization are lacking. There are cases of verrucous candidiasis that progressed to moderate or severe dysplasia, but only one published case of verrucous candidiasis progressed to SCC [ 33 ]. Furthermore, only two population-based studies included skin cancer in evaluating cancer risk in patients with a Candida infection.…”

Section: Candida Skin Colonization and Cancer Developmentmentioning

confidence: 99%

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A Putative Role of Candida albicans in Promoting Cancer Development: A Current State of Evidence and Proposed Mechanisms

et al. 2023

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Candida albicans is a commensal fungal species that commonly colonizes the human body, but it is also a pervasive opportunistic pathogen in patients with malignant diseases. A growing body of evidence suggests that this fungus is not only coincidental in oncology patients, but may also play an active role in the development of cancer. More specifically, several studies have investigated the potential association between C. albicans and various types of cancer, including oral, esophageal, and colorectal cancer, with a possible role of this species in skin cancer as well. The proposed mechanisms include the production of carcinogenic metabolites, modulation of the immune response, changes in cell morphology, microbiome alterations, biofilm production, the activation of oncogenic signaling pathways, and the induction of chronic inflammation. These mechanisms may act together or independently to promote cancer development. Although more research is needed to fully grasp the potential role of C. albicans in carcinogenesis, the available evidence suggests that this species may be an active contributor and underscores the importance of considering the impact of the human microbiome on cancer pathogenesis. In this narrative review, we aimed to summarize the current state of evidence and offer some insights into proposed mechanisms.

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“…Progression of verrucous candidiasis of lip to SCC after 12 months of follow-up. A case report [33] Potential Carcinogenic Mechanisms of C. albicans…”

Section: Skin Cancermentioning

confidence: 99%

Section: Candida Skin Colonization and Cancer Developmentmentioning

confidence: 99%