Verrucous and Papillomatous Types of Sarcoid

Irgang, S.

doi:10.1001/archderm.1950.01530140109011

Cited by 8 publications

(9 citation statements)

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“…Such changes shown histologically to be assoeiated with granulomatous infiltrations of the skin in young blaek men with extensive sarcoidosis were reported by Irgang (1952) and Shmunes et al, (1970).…”

Section: Verrucous and Papillomatous Changesmentioning

confidence: 70%

Sarcoidosis

Scadding

Mitchell

1985

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Section: Verrucous and Papillomatous Changesmentioning

confidence: 70%

Sarcoidosis

Scadding

Mitchell

1985

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“…17 Specific lesions, present in 9%-11% of patients with systemic sarcoidosis, contain noncaseating granulomas in the superficial dermis. 22 Verrucous cutaneous sarcoidosis was first described by Irgang in 1950, and subsequently, only rare cases have been reported in the literature (Table 1). 10 A full spectrum of non-sarcoid inflammatory processes can show sarcoid-like granulomas, as in responses to infectious agents, 18 reactions to foreign material, 19 immunodeficiency disorders, 20 lymphoproliferative disorders, 21 and drug eruptions.…”

Section: Discussionmentioning

confidence: 99%

“…11 Clinically, these may manifest as maculopapules, nodules, plaques, subcutaneous nodules, infiltrative scars, and lupus pernio. [1][2][3][4][5][6][7][8][9] Review of a report of 54 black South Africans with cutaneous manifestations of sarcoidosis and systemic disease revealed one verrucous appearing lesion. 22 Verrucous cutaneous sarcoidosis was first described by Irgang in 1950, and subsequently, only rare cases have been reported in the literature (Table 1).…”

Section: Discussionmentioning

confidence: 99%

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Verrucous Cutaneous Sarcoidosis

Stockman

Rosenberg²,

Bengana

et al. 2013

The American Journal of Dermatopathology

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Sarcoidosis is a multisystem disorder of unknown origin, characterized by the accumulation of lymphocytes and mononuclear histiocytes inducing the formation of noncaseating "naked" epithelioid granulomas. The lungs, lymphatic system, and skin are most often affected, but sarcoidosis may affect any organ. Cutaneous involvement of sarcoidosis is often the sentinel sign of the disease, with the skin sometimes being exclusively affected. We present a case of a 54-year-old African American woman with long-standing history of pulmonary sarcoidosis that presented with multiple verrucous cutaneous lesions on the upper and lower extremities mimicking carcinoma. The initial cutaneous biopsy was superficial in nature, and the pathologist raised the consideration of a possible keratoacanthoma. A deeper skin shave biopsy was performed, and the histopathology showed verrucous pseudoepitheliomatous epidermal hyperplasia with scattered noncaseating granulomas in the superficial dermis. Stains (acid-fast bacillus, Periodic acid-Schiff, and Gomori-Grocott methenamine silver stains) were negative for microorganisms. Given the clinical setting and histomorphology of the cutaneous lesions, the diagnosis of verrucous sarcoidosis was rendered. Verrucous sarcoidosis is a rare cutaneous manifestation of sarcoidosis that could be easily misdiagnosed if it is not appropriately biopsied. This hinders the precise evaluation of the histological specimen, overall clinical picture, and administration of appropriate therapy.

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“…There have been only five reported cases of verrucous sarcoidosis in the English literature. Four out of five cases occurred in young African‐American men 1–4 . The fifth case occurred in a 34‐year‐old African‐American woman 5 .…”

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confidence: 97%