Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan

Sichert, Andreas; Corzett, Christopher H.; Schechter, Matthew S.; Unfried, Frank; Markert, Stephanie; Becher, Dörte; Fernàndez-Guerra, Antonio; Liebeke, Manuel; Schweder, Thomas; Polz, Martin F.; Hehemann, Jan‐Hendrik

doi:10.1038/s41564-020-0720-2

Cited by 209 publications

(243 citation statements)

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“…Verrucomicrobia were first proposed as a new bacterial division (Hedlund et al ., 1997) and later ranked as a separate phylum (Garrity and Holt, 2001) within the Planctomycetes ‐ Verrucomicrobia ‐ Chlamydiae superphylum. They are ubiquitous in freshwater (Zwart et al ., 2003; Arnds et al ., 2010; Chiang et al ., 2018) and have been found in various environments including soils (Janssen, 2006; Bergmann et al ., 2011), oceans (Kasai et al ., 2007; Yoon et al ., 2007b; Yoon et al ., 2007c; Yoon et al ., 2008; Song et al ., 2018; Sichert et al ., 2020) and the gastrointestinal tracts of animals (Isanapong et al ., 2013; Sato et al ., 2014), including humans (Derrien et al ., 2004; Obregon‐Tito et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Freshwater and marine Verrucomicrobia play an important role in global carbon cycling, processing decaying organic materials and degrading various polysaccharides (Cardman et al ., 2014; Cabello‐Yeves et al ., 2017; He et al ., 2017; Sichert et al ., 2020). Genomic studies of marine planktonic Verrucomicrobia have revealed their specialization on certain types of polysaccharides and related their seasonal distribution to dissolved organic matter in seawater (Haro‐Moreno et al ., 2018; Landry et al ., 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Recently discovered ‘ Lentimonas ’ sp. CC4 showed high specialization in degrading sulfated fucoidans in the ocean (Sichert et al ., 2020). The ability to degrade complex sugars ( e .…”

Section: Introductionmentioning

confidence: 99%

“…BMC structures enclose toxic intermediate metabolites to avoid damage to the cell (Sampson and Bobik, 2008; Erbilgin et al ., 2014). A conserved BMC gene cluster encoding aerobic degradation of plant and algal saccharides was annotated in verrucomicrobial symbionts of termites and marine dinoflagellates and in free‐living verrucomicrobial species from soil and marine environments (Erbilgin et al ., 2014; He et al ., 2017; Sichert et al ., 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Genomic studies of marine Verrucomicrobia so far focused mainly on planktonic representatives (Freitas et al ., 2012; Yang et al ., 2016; Sichert et al ., 2020). Despite having been extensively described as symbionts of many marine invertebrates [ e .…”

Section: Introductionmentioning

confidence: 99%

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Characterization of sponge‐associated Verrucomicrobia: microcompartment‐based sugar utilization and enhanced toxin–antitoxin modules as features of host‐associated Opitutales

Sizikov

Burgsdorf

Lahyani

et al. 2020

Environmental Microbiology

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Summary Bacteria of the phylum Verrucomicrobia are ubiquitous in marine environments and can be found as free‐living organisms or as symbionts of eukaryotic hosts. Little is known about host‐associated Verrucomicrobia in the marine environment. Here we reconstructed two genomes of symbiotic Verrucomicrobia from bacterial metagenomes derived from the Atlanto‐Mediterranean sponge Petrosia ficiformis and three genomes from strains that we isolated from offshore seawater of the Eastern Mediterranean Sea. Phylogenomic analysis of these five strains indicated that they are all members of Verrucomicrobia subdivision 4, order Opitutales. We compared these novel sponge‐associated and seawater‐isolated genomes to closely related Verrucomicrobia. Genomic analysis revealed that Planctomycetes‐Verrucomicrobia microcompartment gene clusters are enriched in the genomes of symbiotic Opitutales including sponge symbionts but not in free‐living ones. We hypothesize that in sponge symbionts these microcompartments are used for degradation of l‐fucose and l‐rhamnose, which are components of algal and bacterial cell walls and therefore may be found at high concentrations in the sponge tissue. Furthermore, we observed an enrichment of toxin–antitoxin modules in symbiotic Opitutales. We suggest that, in sponges, verrucomicrobial symbionts utilize these modules as a defence mechanism against antimicrobial activity deriving from the abundant microbial community co‐inhabiting the host.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Recently discovered ‘ Lentimonas ’ sp. CC4 showed high specialization in degrading sulfated fucoidans in the ocean (Sichert et al ., 2020). The ability to degrade complex sugars ( e .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of sponge‐associated Verrucomicrobia: microcompartment‐based sugar utilization and enhanced toxin–antitoxin modules as features of host‐associated Opitutales

Sizikov

Burgsdorf

Lahyani

et al. 2020

Environmental Microbiology

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Association between gut microbiota and malignant cardiac tumors: A two‐sample Mendelian randomization study

Song,

Hu,

et al. 2024

Cancer Medicine

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BackgroundRecent studies provide compelling evidence linking the gut microbiota to most cancers. Nevertheless, further research is required to establish a definitive causal relationship between the gut microbiota and malignant cardiac tumors.MethodsThe genome‐wide association studies (GWAS) data on the human gut Microbiota, included in the IEU Open GWAS project, was initially collected by the MiBioGen consortium. It encompasses 14,306 individuals and comprises a total of 5,665,279 SNPs. Similarly, the GWAS data on malignant cardiac tumors, also sourced from the IEU Open GWAS project, was initially stored in the finnGen database, including 16,380,303 SNPs observed within a cohort of 174,108 individuals within the European population. Utilizing a two‐sample Mendelian randomization (MR) methodology, we examined whether there exists a causal association between the gut microbiota and cardiac tumors. Additionally, to bolster the credibility and robustness of the identified causal relationships, we conducted an extensive array of sensitivity analyses, encompassing Cochran's Q test, MR‐PRESSO tests, MR‐Egger interpret test, directionality test and leave‐one‐out analysis.ResultsOur analysis unveiled seven distinct causal associations between genetic susceptibility in the gut microbiota and the incidence of malignant cardiac tumors. Among these, the Family Rikenellaceae, genus Eubacterium brachy group, and genus Ruminococcaceae UCG009 exhibited an elevated risk of cardiac tumors, while the phylum Verrucomicrobia, genus Lactobacillus, genus Ruminiclostridium5, and an unknown genus id.1868 were genetically linked to a reduced risk of cardiac tumors. The causal relationship between these two bacteria, belonging to the phylum Verrucomicrobia (OR = 0.178, 95% CI: 0.052–0.614, p = 0.006) and the genus Ruminococcaceae UCG009 (OR = 3.071, 95% CI: 1.236–7.627, p = 0.016), and cardiac tumors was further validated through sensitivity analyses, reinforcing the robustness and reliability of the observed associations.ConclusionOur MR analysis confirms that the phylum Verrucomicrobia displays significant protection against cardiac tumor, and the genus Ruminococcaceae UCG009 leads to an increasing risk of cardiac tumor.

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Taking Synthetic Biology to the Seas: From Blue Chassis Organisms to Marine Aquaforming

Borzyskowski

2023

ChemBioChem

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Oceans cover 71 % of Earth's surface and are home to hundreds of thousands of species, many of which are microbial. Knowledge about marine microbes has strongly increased in the past decades due to global sampling expeditions, and hundreds of detailed studies on marine microbial ecology, physiology, and biogeochemistry. However, the translation of this knowledge into biotechnological applications or synthetic biology approaches using marine microbes has been limited so far. This review highlights key examples of marine bacteria in synthetic biology and metabolic engineering, and outlines possible future work based on the emerging marine chassis organisms Vibrio natriegens and Halomonas bluephagenesis. Furthermore, the valorization of algal polysaccharides by genetically enhanced microbes is presented as an example of the opportunities and challenges associated with blue biotechnology. Finally, new roles for marine synthetic biology in tackling pressing global challenges, including climate change and marine pollution, are discussed.

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Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan

Cited by 209 publications

References 108 publications

Characterization of sponge‐associated Verrucomicrobia: microcompartment‐based sugar utilization and enhanced toxin–antitoxin modules as features of host‐associated Opitutales

Characterization of sponge‐associated Verrucomicrobia: microcompartment‐based sugar utilization and enhanced toxin–antitoxin modules as features of host‐associated Opitutales

Association between gut microbiota and malignant cardiac tumors: A two‐sample Mendelian randomization study

Taking Synthetic Biology to the Seas: From Blue Chassis Organisms to Marine Aquaforming

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