Verruciform xanthoma in a patient with recessive dystrophic epidermolysis bullosa: Case report and literature review

Abstract

Verruciform xanthoma (VX) is a rare finding thought to be caused by epidermal damage from trauma or inflammation and has been reported in a limited number of patients with recessive dystrophic epidermolysis bullosa (RDEB). Herein, we describe a 20‐year‐old woman with RDEB who developed a large, verrucous, pink plaque on the posterior thigh that was histologically proven to be a VX. We review cases of VX in patients with RDEB and summarize the clinical features, pathophysiology, and management principles.

Unusual plaque in a patient with recessive dystrophic epidermolysis bullosa

“…3,5 When asymptomatic, VX can simply be observed. 6 Our patient chose observation since he was asymptomatic.…”

“…It is important for clinicians to consider verruciform xanthoma in their differential diagnosis of verrucous papules or plaques in this subset of patients as VX lesions can easily be mistaken clinically for squamous cell carcinoma, a tumor which RDEB patients are at increased risk for developing. 6,7 O RCI D Caroline S. Zhu https://orcid.org/0000-0003-3732-6031…”