Verrucae Treated by Levamisole

Abstract

To assess the role of levamisole in treatment of different types of warts, a double-blind study was conducted on 40 patients with different types of warts. Patients were divided into two equal groups, A and B. Group A received levamisole 5 mg/kg body weight on 3 consecutive days every 2 weeks for a period up to 5 months, while patients of group B received placebo for the same period. In group A, 12 patients showed complete cure (60%), two showed partial cure (10%), and the remaining six patients showed no response (30%). In group B, complete cure was achieved only in one case. The higher cure rate was observed in plane and common warts, while plantar warts showed no improvement with levamisole treatment.

An Armamentarium of Wart Treatments

“…227 Levamisole Levamisole is another immunomodulating drug that has been used effectively in the treatment of flat and common warts with moderate success. 228 Imiquimod Imiquimod 5% cream is an immunomodulator that may stimulate cytokines, including interferon-α, interleukin-1, interleukin-6, tumor necrosis factor-α, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor. 83 Absorption of imiquimod through intact skin is minimal.…”

Levamisole Monotherapy for Oral Lichen Planus

“…In 1990, the FDA approved levamisole for many autoimmune and inflammatory diseases. Levamisole is currently used for the treatment of vitiligo, viral warts, systemic lupus erythematosus, rheumatoid arthritis and colon cancer [22][23][24][25][26][27][28][29] .…”

“…Levamisole is an effective immunomodulating agent that can restore the normal phagocytic activity of macrophages and neutrophils, it modulates T-cell mediated immunity and it potentiates the activity of human interferon [17][18][19][20][21] . It is used to treat several malignancies and autoimmune diseases (for example, rheumatoid arthritis and systemic lupus erythematosus), vitiligo and viral warts [22][23][24][25][26][27][28][29] .…”

Verrucae planae juveniles

“…1 8 Multiple Verrucae planae juveniles periorbital, an der linken Wange und an der Stirn links seit 2 Jahren (vor Therapie) Abb. 2 8 Vollständige und narbenfreie Abheilung nach nur 4 Wochen Therapie (2-mal pro Woche) mit Imiquimod 5% Creme Therapieoptionen Verrucae planae juveniles im Gesicht stellen schon aufgrund der Lokalisation, v. a. aber bei Kindern, besondere Ansprüche an die Behandlung.…”

“…Alternativ zur immunmodulatorischen Therapie mit Imiquimod kann eine photodynamische Therapie [5] oder eine CO 2 -Laserabtragung erwogen werden. Die Therapie mit dem Immunmodulator Levamisole zeigte in einer Studie in 60% der Fäl-le eine Vollremission [1].…”