Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae)

Tchinda, Alembert T.; Tsopmo, Apollinaire; Tane, Pierre; Ayafor, J. Foyere; Connolly, Joseph D.; Sterner, Olov

doi:10.1016/s0031-9422(01)00448-4

Cited by 44 publications

(28 citation statements)

References 6 publications

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“…Previous studies have shown that the DCM and hexane fractions from the extract have fungicidal and bactericidal properties (2). Also, many Vernonia species are used as trypanocidal (28), antiplasmodial (29) and anthelmintic agents (30).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Pagno

Blind

Biavatti

et al. 2006

Braz J Med Biol Res

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Vernonia scorpioides has been widely used in Brazil to treat skin problems and chronic wounds, such as ulcers of the lower limbs and diabetic lesions. In the present study, we investigated the effect of a dichloromethane (DCM) fraction of V. scorpioides leaf extract on Ehrlich ascitic and solid tumor-bearing mice. The animals were treated once a day with the DCM fraction at a concentration of 5 mg/kg, administered ip during and after the development of the tumor. The lifespan, weight, number and type of leukocytes, number of tumor cells, volume of solid and ascitic tumors were measured. The development of the tumor with pre-treated tumor cells in vitro with the DCM fraction (5 mg/kg) was analyzed and the animals were sacrificed after 7 days. The DCM fraction (5 mg/kg) totally inhibited tumor development when in direct contact with tumor cells, and also ascitic tumor development with in vitro treatment or when administered ip, in loco (after 7 days). Animals treated with the DCM fraction increased their lifespan ca. 2 weeks and maintained their body weight for 30 days. When applied immediately after the inoculation of the tumor cells in vivo, it totally abolished tumor development, with tumor development only decreasing when treatment was started 3 days after the tumor challenge. These data suggest an antineoplastic activity of the fraction. Oral or ip administration of DCM fraction (5 mg/kg) for 7 days did not reduce the solid tumor volume. The cytotoxic activity described here differs from the conventional immune suppressing profile of standard chemotherapy because it increases neutrophil influx to the peritoneal cavity. These results show that, besides exhibiting a tumoricidal activity, the DCM fraction also exhibits inflammatory activity.

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Section: Discussionmentioning

confidence: 99%

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Pagno

Blind

Biavatti

et al. 2006

Braz J Med Biol Res

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“…Members of genus Vernonia were well known for the production of sesquiterpene lactones and stigmastane-type steroids and steroidal glycosides [4][5][6][7][8]. In our previous paper, from the aerial parts of this species, eleven Δ 8,14 stigmastane-type steroids and steroidal glycosides were isolated [9].…”

Section: Introductionmentioning

confidence: 99%

Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd

Liu

Wang

et al. 2012

Fitoterapia

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“…Vernonia guineensis is use in ethnomedicine as an adaptogen to combat stress and as a stimulant. The plant is also used as an anthelmintic, an aphrodisiac, an antidote to poison, and to treat malaria and jaundice (Iwu, 1993;Tchinda et al, 2002). Noumi (2010) reported that the root decoction is used to treat prostate cancer and prostatitis in Cameroon.…”

Section: Introductionmentioning

confidence: 99%

“…Tchinda et al (2002Tchinda et al ( , 2003 reported the isolation of stigmatane derivatives and two sucrose ester type compounds from Vernonia guineensis Benth tubers. One of the stigmatane showed anti-trypanocidal activity.…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-prostate cancer and ex vivo antiangiogenic activity of Vernonia guineensis Benth. (Asteraceae) tuber extracts

Toyang¹,

Wabo²,

Ateh³

et al. 2012

Journal of Ethnopharmacology

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Vernoguinosterol and vernoguinoside, trypanocidal stigmastane derivatives from Vernonia guineensis (Asteraceae)

Cited by 44 publications

References 6 publications

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice

Biologically active steroids from the aerial parts of Vernonia anthelmintica Willd

In vitro anti-prostate cancer and ex vivo antiangiogenic activity of Vernonia guineensis Benth. (Asteraceae) tuber extracts

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