Vernocistifolide und andere Sesquiterpenlactone aus <i>Vernonia</i> und verwandten Arten

Jakupovic, Jasmin; Zdero, Christa; Boeker, R.; Warning, U.; Bohlmann, Ferdinand; Jones, Sarah Bruyn

doi:10.1002/jlac.198719870204

Cited by 32 publications

(13 citation statements)

References 26 publications

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“…5; Table 2). They are already known from V. colorata and were identified by comparison of their spectral data ( 1 H-NMR, 13 C-NMR EI-MS and FAB-MS) with published values (Ganjian et al, 1983;Jakupovic et al, 1987). Interestingly, no flavonoids could be detected.…”

Section: Resultsmentioning

confidence: 99%

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In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe

Kraft

Jenett‐Siems

Siems³

et al. 2003

Phytotherapy Research

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147

107

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In this study the in vitro antiplasmodial activities of extracts from Cussonia spicata (Araliaceae), Artemisia afra, Vernonia colorata, V. natalensis (Asteraceae), Parinari curatellifolia (Chrysobalanaceae), Clutia hirsuta, Flueggea virosa, (Euphorbiaceae), Adenia gummifera (Passifloraceae) and Hymenodictyon floribundum, (Rubiaceae) were evaluated. The lipophilic extracts from the aerial parts of Artemisia afra and Vernonia colorata proved to be the most active against the chloroquine-sensitive strain PoW and against the chloroquine-resistant clone Dd2 of Plasmodium falciparum. Bioassay-guided fractionation of the extract of A. afra yielded seven flavonoids, from which acacetin, genkwanin and 7-methoxyacacetin showed in vitro activity; the IC(50) values ranged from 4.3 microgram/mL to 12.6 microgram/mL. In addition, several sesquiterpene lactones could be obtained from the most active fractions. Whereas eudesmaafraglaucolide proved to be inactive, the guaianolides 1-desoxy-1alpha-peroxy-rupicolin A-8-O-acetate, 1alpha,4alpha-dihydroxybishopsolicepolide and rupicolin A-8-O-acetate revealed in vitro antiplasmodial activity. Evaluation of V. colorata gained four sesquiterpenes 11beta,13-dihydrovernodalin, vernodalol, 11beta,13-dihydrovernolide and 11beta,13,17,18-tetrahydrovernolide, from which the first two constituents exhibited the strongest antiplasmodial activity (IC(50) values: 1.1-4.8 microgram/mL).

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Section: Resultsmentioning

confidence: 99%

“…C-NMR EI-MS and FAB-MS) with published values (Ganjian et al, 1983;Jakupovic et al, 1987). Interestingly, no flavonoids could be detected.…”

mentioning

confidence: 88%

In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe

Kraft

Jenett‐Siems

Siems³

et al. 2003

Phytotherapy Research

Self Cite

147

107

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“…Distephanus and Vernonia are closely related genera within the Asteraceae (Robinson, 2006), but whereas phytochemical information on Distephanus is scarce (Jakupovic et al, 1987), Vernonia is known to be a rich source of sesquiterpene lactones. Vernonia amygdalina is probably one of the most intensively investigated Vernonia species due to reports of its use as an antiparasitic remedy by wild chimpanzees (Huffman and Seifu, 1989;Jisaka et al, 1992; Contents lists available at ScienceDirect Phytochemistry j o u r n a l h o m e p a g e : w w w .…”

Section: Introductionmentioning

confidence: 99%

Antimalarial sesquiterpene lactones from Distephanus angulifolius

et al. 2009

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Combined use of bioassay-guided fractionation based on in vitro antiplasmodial assay and dereplication based on HPLC-PDA-MS-SPE-NMR led to isolation of (6S,7R,8S)-14-acetoxy-8-[2-hydroxymethylacrylat]-15-helianga-1(10),4,11(13)-trien-15-al-6,12-olid and (5R,6R,7R,8S,10S)-14-acetoxy-8-[2-hydroxymethylacrylat]-elema-1,3,11(13)-trien-15-al-6,12-olid, along with vernodalol, vernodalin, and 11,13beta-dihydroxyvernodalin from extract of Distephanus angulifolius. All compounds were identified by spectroscopic methods, including 1D and 2D homo- and heteronuclear NMR experiments. The isolated compounds showed IC(50) values in the range 1.6-3.8 microM and 2.1-4.9 microM against chloroquine sensitive D10 and chloroquine resistant W2 Plasmodium falciparum strains, respectively.

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“…Its phytochemical composition and the effect of its aqueous extract on cockroach crude extract-induced airway inflammatory responses in Wistar Rats has been reported by Eko et al (2008). Sesquiterpine lactone has been isolated from the plant as reported by Jakupovic et al (1987). Although a lot had been reported on the chemical characterization of phytoconstituents and antioxidant properties of Struchium sparganophora, however, limited information is available on the possible mechanism by which Struchium sparganophora is being used in traditional medicine in the management/prevention of type-2 diabetes.…”

Section: Introductionmentioning

confidence: 94%

“…It is a green leafy vegetable popularly used in soup preparations in processed and unprocessed forms in Nigeria. It is also widely used medicinally in a number of countries: decoction of the stem and root are employed in the treatment of diabetes mellitus, headaches, gonorrhea (Jakupovic et al, 1987;Akah and Ekekwe, 1995). In the Sao Tome and Principe (STP) island (Gulf of Guinea), it is used for the treatment of malaria (Heywood et al, 1977;Madureira et al, 2002) and in the treatment of measles (Burkill, 1985).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant properties and inhibitory effect of ethanolic extract of <i>Struchium sparganophora</i> (Ewuro odo) leaf on α - amylase and α – glucosidase activities

Oboh¹,

Akinyemi²,

Ademiluyi³

2012

Afr. J. Trad. Compl. Alt. Med.

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Recent studies have shown that vegetables consumption could lower the risk of diabetes mellitus. Therefore, this study sought to investigate the inhibitory effect of Struchium sparganophora (Ewuro Odo) leaf on key enzyme linked to type-2 diabetes (α-amylase and α-glucosidase) as well as assessing the effect of blanching (a commonly practiced food processing technique) of this leafy vegetable on these key enzymes. Fresh leaves of Struchium sparganophora were blanched in hot water for 10 minutes, and the 70% ethanolic extracts of the fresh and blanched vegetables were prepared and used for subsequent analysis. The antioxidant properties and interaction of the extracts on α -amylase and α -glucosidase activities was determined in vitro. The result revealed that Struchium sparganophora leaf scavenged DPPH free radical and also inhibited α -amylase and α -glucosidase activities in a dose dependent manner (0.05 -0.2 mg/ml). However, blanching of this leafy vegetables caused a significant (P<0.05) increase in the antioxidant properties as typified by the DPPH radical scavenging ability and reducing property but decrease their ability to inhibit α -amylase and α -glucosidase activities. This antioxidant properties and enzyme inhibition could be part of the mechanism by which green leafy vegetables exert their anti-diabetic properties. However, blanching of the vegetable could reduce their ability to inhibit both α -amylase and α -glucosidase activity, but enhance their antioxidant properties in vitro.

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Vernocistifolide und andere Sesquiterpenlactone aus Vernonia und verwandten Arten

Cited by 32 publications

References 26 publications

In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe

In vitro antiplasmodial evaluation of medicinal plants from Zimbabwe

Antimalarial sesquiterpene lactones from Distephanus angulifolius

Antioxidant properties and inhibitory effect of ethanolic extract of <i>Struchium sparganophora</i> (Ewuro odo) leaf on α - amylase and α – glucosidase activities

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