Vernal keratoconjunctivitis and keratoconus

Wajnsztajn, Denise; Solomon, Abraham

doi:10.1097/aci.0000000000000765

Cited by 31 publications

(25 citation statements)

References 58 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore in patients affected by VKC itching induces eye rubbing with corneal epithelium microtrauma and damage. This, in susceptible individuals, can lead to cytokines release, myofibroblastst differentiation, biomechanical forces change and corneal tissue thinning with development of keratoconus [8,9], a frequent complication of both VKC [10] and DS [1]. Therefore, our case suggests important implications for diagnostic workup and treatment.…”

Section: Discussionmentioning

confidence: 87%

Vernal keratoconjunctivitis in Down syndrome: a case report

et al. 2023

View full text Add to dashboard Cite

Background Down syndrome (DS) or Trisomy 21 is the most common chromosomal disease and is characterized by possible heart defects, cognitive impairment and visual disorders. Case presentation We describe for the first time a 17-year-old Caucasian girl suffering from Down syndrome associated with vernal keratoconjunctivitis (VKC), a rare disorder of the anterior segment of the eye, characterized by intense photophobia, redness, watering eyes and itching due to an inflammatory-allergic reaction of the cornea and conjunctiva. On slit-lamp examination, the girl showed conjunctival hyperemia, papillary hypertrophy, giant papillae and corneal leukoma in right eye as a result of a previous corneal ulcer. A successful topical immunosuppressant therapy with cyclosporin 1% was started. Conclusion So far, to our knowledge, this is the first description of VKC in a patient with DS. Finding an inflammatory-allergic disease such as VKC in DS is unusual but it must be taken into account because keratoconus, one of the most frequent eye pathologies in DS, can be secondary to an unrecognized VKC.

show abstract

Section: Discussionmentioning

confidence: 87%

Vernal keratoconjunctivitis in Down syndrome: a case report

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Our study and other previous studies suggest that AC patients may be at higher risk for impairment in retinal structure, dry eye, myopia, and keratopathy (corneal ulcers, pannus, keratoconus, etc.) [10,[22][23][24]. Therefore, ophthalmologists may need to monitor AC patients for the changes in refraction, ocular surface, fundus and other ocular diseases.…”

Section: Discussionmentioning

confidence: 99%

Altered retinal nerve fiber layer thickness in children with allergic conjunctivitis: the Nanjing eye study

Chen

Huang

et al. 2022

BMC Ophthalmol

View full text Add to dashboard Cite

Background So far, few data are available on the relationship between allergic conjunctivitis (AC) and ocular fundus. Whether retinal parameters change in patients with AC remains unknown. In this study, we investigated the influence of AC on retinal thickness and vessel density among 7-years-old school-age children. Methods This large population-based study is part of the Nanjing Eye Study (NES). Comprehensive examinations including anthropometric parameters, refraction, ocular biometric parameters, intraocular pressure and retinal parameters were conducted on each child. Retinal thickness and vessel density were assessed using the optical coherence tomography angiography. Information on AC was obtained from a comprehensive questionnaire. Results A total of 739 children (mean age ± SD: 7.40 ± 0.29 years) had complete eye examination and questionnaire data we needed. Ninety-four children (12.7%) had AC, among which, 5 children had the history of corticosteroid use and were excluded from the final analysis. Spherical equivalent, axial length, body mass index and birth weight were correlated with retinal parameters. After adjusting for sex, age, spherical equivalent, axial length, body mass index, birth weight and premature history, children with AC had thinner retinal nerve fiber layer thickness for average (117.39 versus 120.97 μm, p = 0.007), temporal (80.73 versus 84.34 μm, p = 0.001), nasal (98.82 versus 102.18 μm, p = 0.049) and inferior (152.68 versus 157.06 μm, p = 0.034) quadrants than the control group. Conclusions Children with AC tended to have thinner retinal nerve fiber layer thickness. More attention is needed to fundus condition of children with AC.

show abstract

“…Indeed, intolerable symptoms of itching, photophobia, mucoid discharge, redness and foreign body sensation may be severe enough to incapacitate the subject, hindering the performance of daily activities [1,3,4,7]. Some patients are unable to stop rubbing their eyes, potentially leading to keratoconus and significant visual deterioration [7,19]. Thus, alleviating the signs and symptoms of ACD as soon as possible is of great value in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial

Chen

Zou

et al. 2022

JCM

View full text Add to dashboard Cite

This study sought to evaluate the efficacy of the isolated use of fluorometholone compared with the combined use of azelastine and fluorometholone for the treatment of severe allergic conjunctival disease (ACD). One hundred and eleven patients with severe ACD were randomized into two groups: one treated with topical 0.1% fluorometholone combined with 0.05% azelastine and the other with 0.1% fluorometholone alone. The Ocular Surface Disease Index (OSDI) and the signs of keratopathy, palpebral conjunctiva papillae and conjunctival congestion were scored before and at one, two and six weeks after treatment and compared between the groups. The intra-ocular pressure (IOP) was also monitored. There were no significant differences between the groups in the baseline mean scores of signs and OSDI scores, which gradually improved at all visits after therapy in both groups. Although the time effect was significant for all the parameters (all p < 0.001), the reduction in corneal involvement scores from week 2 to week 6 was insignificant in both groups (p = 0.460 for the steroids group and p = 0.074 for the combination group). All signs and symptoms were significantly more improved in the combination group than in the isolated group at each control visit. IOP remained stable at all visits (all p < 0.001), except one patient in each group had elevated IOP over 21 mmHg. While both the isolated use of fluorometholone and combined use of azelastine and fluorometholone are effective in alleviating the signs and symptoms of severe ACD, optimal response can be achieved with adjunctive treatment including azelastine.

show abstract

Vernal keratoconjunctivitis and keratoconus

Cited by 31 publications

References 58 publications

Vernal keratoconjunctivitis in Down syndrome: a case report

Vernal keratoconjunctivitis in Down syndrome: a case report

Altered retinal nerve fiber layer thickness in children with allergic conjunctivitis: the Nanjing eye study

Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial

Contact Info

Product

Resources

About