Vermehrte hepatische Schädigung und Induktion von Stammzellen in einem Modell der sklerosierenden Cholangitis bei fehlender Protektion durch gp130/STAT3

940 Loss of Keratin 19 Predisposes to the Development of Cholestatic Liver Disease

“…Chronic feeding with a diet containing 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) represents a well-established murine model of xenobiotic-induced cholestatic disease [124,[128][129]. Long-term treatment with this porphyrinogenic drug leads to formation of protoporphyrin plugs that obstruct intrahepatic bile ducts thereby resulting in biliary injury peaking at 4 weeks after beginning of DDC treatment.…”