Verlauf des Adsorptionsprozesses bei der Einwirkung des Phenols auf Bakterien

Küster, E.; Rothaub,

doi:10.1007/bf02216443

Cited by 8 publications

(1 citation statement)

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“…The investigations of Brooks, 9 Ktister and Rothaub, 12 Cooper, 1~ Traube, 14 Clowes and Keith, 15 and Traube and Somogyi, 1~ are sufficient to show that a strictly chemical (monomolecular) interpretation of poisoning (or disinfection) offers an entirely inadequate description of the mechanisms involved. The results of the writer show that a straight line describes the progress of poisoning by phenols with precision when a vital factor, namely the variability in resistance of individual organisms, is taken into account.…”

Section: IIImentioning

confidence: 99%

Studies in Protoplasm Poisoning

Shackell

1923

Journal of General Physiology

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1. After equilibrium of distribution of a phenol between water and an animal immersed in it has been once attained, the poisoning of the animal proceeds with constant velocity. The criterion of toxicity adopted in the first part of this study was the time required for initial recovery from paralysis after a given time in the phenol solution. In later work observations were made of the percentages of animals which died after stated periods in a phenol solution. 2. The numerical value of the velocity constant of poisoning for a given solution is independent of the criterion of toxicity adopted, provided that the criterion serves to measure the intensity of effect of the poison, and not merely the rate at which the poison is absorbed. 3. Recovery from paralysis produced by phenol and death from this poison has the same velocity constant. From this it may be inferred that recovery is due to a reversal of the mechanism which underlies poisoning. 4. The velocity of poisoning by phenols is nearly proportional to the square of the concentration. 5. A strictly chemical (mass law) interpretation is shown to be inadequate for the description of poisoning by phenols. 6. Certain physical factors, involved in poisoning by phenols, are discussed. 7. A precise method for obtaining the velocity constant of poisoning by a given agent is outlined.

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Section: IIImentioning

confidence: 99%