for the affected regions. The aim of this study is to describe the issues with diphtheria case notifications and ORI uptake rate for the Asian Games and Asian Para Games Venues. Data were collected from the National surveillance dataset and Provincial Health Offices of the four provinces via the surveillance district officers. Routine immunization coverage, diphtheria cases and ORI coverage from four respective provinces from January 2017 to 31 October 2018. All notifications and reference laboratory data were used. The variables were analyzed descriptively in tables, graph, and map. A total of 260 cases were reported in 11 districts in South Sumatra, West Java, Jakarta, and Banten. One case was excluded because of missing data. There were 129 case notifications within the target age group of interest. The first round of immunization uptake rate was poor during the outbreak immunization response (ORI). However, for the second round improved in most of the districts. The decline in cases in most districts can be attributed to the quick response of the health authorities to contain the outbreak. They implemented measures including active case finding, contact tracing and an active increase in risk communication and public health education, especially focused on vulnerable groups for the target age groups between the ages of 1 to 18 years old. Highly dense urban areas in the affected provinces with the highest incident rates were also targeted in areas of mass gathering (e.g. shopping centers). Neighboring areas around the venues of the Asian Games 2018 were also targeted as areas to improve immunization rates.