Verifying Sarcoidosis Activity: Chitotriosidase Versus ACE in Sarcoidosis – A Case-Control Study

Popević, Spasoje; Šumarac, Zorica; Jovanović, Dragana; Babić, Dragan; Stjepanović, Mihailo; Jovičić, Snežana; Šobić-Šaranović, Dragana; Filipović, Snežana; Gvozdenović, Branko; Omcikus, Maja; Milovanović, Aleksa; Videnović-Ivanov, Jelica; Radović, Ana; Zugic, Vladimir; Mihailović-Vučinić, Violeta

doi:10.1515/jomb-2016-0017

Cited by 43 publications

(45 citation statements)

References 28 publications

(47 reference statements)

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“…In the literature, different results have been reported regarding the serum ACE level in patients with extrapulmonary involvement. The serum ACE level has been reported to be elevated in cases with extrapulmonary involvement in some studies, whereas no difference has been reported in others (23,32,33). We have the opinion that this might also be related to the racial variability of serum ACE level due to the ACE gene polymorphism.…”

Section: Discussionmentioning

confidence: 71%

“…Various results are present in the literature regarding ACE. In some studies, it was stated that the serum ACE level did not change according to the radiological stage and was not correlated with the severity of the disease (22)(23)(24). In the study by Lammi et al, the serum ACE level was reported to be higher in stage-2 and stage-3 patients having parenchymal involvement when compared to those with no involvement of parenchyma (stage 0, 1) (16).…”

Section: Discussionmentioning

confidence: 99%

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The Role of Serum Angiotensin Converting Enzyme for Predicting Pulmonary Parenchymal and Extrapulmonary Involvement of Sarcoidosis

Yazici¹,

Karadağ²,

Ceylan³

et al. 2019

Kocaeli Med J

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Sarkoidoz günümüzde halen etiyolojisi bilinmeyen bir hastalıktır. Klinik tablo ve seyir hastalığın başlangıç yaşına, süresine, evresine ve yaygınlığına bağlı olarak değişmektedir. Klinik tabloyu ve seyri öngörebilecek biyomarkerların kullanılması hastalığın yönetiminde kolaylık sağlayacaktır. Çalışmamızda hematolojik ve biyokimyasal parametrelerle hastalığın evre ve yaygınlığı arasındaki ilişkiyi belirlemeyi amaçladık. YÖNTEM ve GEREÇLER: 2013-2018 yılları arasında kliniğimizde sarkoidoz tanısı konulan hastaların dosyaları retrospektif olarak incelendi. Hastaların demografik verileri, tanı sırasındaki klinik bulguları, evreleri, ekstrapulmoner tutulum olup olmadığı ve hemogram, eritrosit sedimentasyon hızı (ESR), C reaktif protein (CRP), serum kalsiyum (Ca) ve anjiotensin konverting enzim (ACE) düzeylerini içeren laboratuvar parametreleri kaydedildi. Hastalar akciğer parankim tutulumu ve ekstrapulmoner tutulumu olup olmamasına göre sınıflandırıldı. Akciğer parankim tutulumu olmayan evre 1 hastalar grup 1 ve akciğer parankim tutulumu olan evre 2 ve 3 hastalar grup 2 olarak sınıflandırıldı. BULGULAR: Belirlenen tarihler arasında 121 sarkoidoz hastasının verilerine ulaşıldı. Hastaların 30 (%24.8)'u erkek, 91 (%75.2)'i kadın ve yaş ortalaması 50.71±11.76 idi. Grup 1'de 59 (%48,8) ve grup 2'de 62 (%51,2) olgu vardı. Hastaların 71 (%58,9)'de sadece akciğer tutulumu varken 50 (%41.3)'sinde akciğer ve akciğer dışı organ tutulumu birlikte vardı. Akciğer dışı organ tutulumu en sık eritema nodozum (EN)'du (%15,7). Grup 2 olgularda serum ACE değeri grup 1'den daha yüksekti (p =0,027). Akciğer ve akciğer dışı tutulumu olan olgularda serum ACE düzeyi akciğer dışı tutulum olmayanlara göre daha yüksekti (p =0,045). Bakılan diğer laboratuvar parametreleri gruplar arasında farklı değildi. TARTIŞMA ve SONUÇ: Serum ACE düzeyi akciğer parankim tutulumunu ve ekstrapulmoner tutulumu göstermede faydalı olabilir.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

The Role of Serum Angiotensin Converting Enzyme for Predicting Pulmonary Parenchymal and Extrapulmonary Involvement of Sarcoidosis

Yazici¹,

Karadağ²,

Ceylan³

et al. 2019

Kocaeli Med J

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“…According to a study on 232 sarcoidosis patients by Bargagli et al [15] the enzyme chitotriosidase is also correlating to ACE and showed for sarcoidosis a high sensitivity (88.6%) and specificity (92.8%). In a study by Popevic et al [16] the corresponding values for sensitivity were 82.5% and for specificity 70%. Serum-ACE in the latter study had 66% sensitivity and 54% specificity.…”

Section: Discussionmentioning

confidence: 90%

Lung CD4+ Vα2.3+ T-cells in sarcoidosis cohorts with Löfgren’s syndrome

et al. 2020

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Background: Sarcoidosis is diagnosed by a combination of typical clinical and radiological findings together with biopsy proof of non-caseating epithelioid cell granulomas in affected tissues and/or the cell distribution in bronchoalveolar lavage fluid (BALF). We aimed at investigating the usefulness of measuring the proportion of T-cell receptor (TCR) CD4+ Vα2.3+ T-cells in BALF as an additive marker to CD4/CD8-ratio to confirm the diagnosis. Methods: From a register consisting of 749 sarcoidosis patients [Löfgren's syndrome (LS) n = 274, non-LS n = 475] with information on Vα2.3+ T-cells, an expansion of CD4+ Vα2.3+ T-cells (CD4+ Vα2.3+ T cells > 10.5% in BALF) was seen in 268 (36%). Controls were healthy volunteers (n = 69) and patients with other pulmonary conditions (n = 39), investigated because of suspicion of sarcoidosis. Results: A proportion of CD4+ Vα2.3+ T-cells in BALF > 10.5% was highly specific for sarcoidosis, with a specificity of 97% and with a sensitivity of 36% (p < 0.0001). Receiver operating characteristic (ROC) curves show that testing for CD4+ Vα2.3+ T-cells in BALF was a more useable test in individuals with LS [area under the curve (AUC) 0.82, p < 0.0001] compared to the whole patient group (AUC 0.64, p < 0.0001). Conclusion: In this study, we show that an increased proportion of CD4+ Vα2.3+ T-cells in BALF is highly specific for sarcoidosis. This suggests that this T-cell subset could be used as an additional tool to the CD4/CD8-ratio to support the sarcoidosis diagnosis, particularly in patients with LS but also in patients with non-LS.

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“…In everyday clinical practice, CHIT1 is used as a circulating biomarker for monitoring the efficacy of various therapeutic approaches in Gaucher's disease where is considered to be a surrogate serum biomarker of the tissue lipid-laden macrophages known as Gaucher cells [40,41]. Elevated CHIT1 was also observed in various other disorders characterized by nonspecific macrophage activation and expansion, such as β-thalassemia [42,43], Plasmodium falciparum malaria [44], sarcoidosis [45][46][47] and Wegener's granulomatosis [48].…”

Section: Introductionmentioning

confidence: 99%