Verification of two minimally invasive methods for the estimation of the contact pressure in human vocal folds during phonation

Chen, Li‐Jen; Mongeau, Luc

doi:10.1121/1.3613708

Cited by 17 publications

(27 citation statements)

References 26 publications

(30 reference statements)

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“…In agreement with prior work that employed animal hemilarynx models [12,37], silicone vocal fold models [10,36], and numerical modeling [40], the intraglottal pressure signal in the current human excised larynx study exhibited both contact/collision and aerodynamic components separated in time. In particular, sweeping the vertical (superior-inferior) position of the pressure sensor from a supraglottal to a subglottal location was performed to mimic the experimental protocol of [10].…”

Section: Comparison Of Results To Prior Worksupporting

confidence: 87%

Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models

et al. 2019

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Featured Application: The goal of the current work is to validate a method for simultaneous measurement of vocal fold collision and subglottal pressures that can be used in vivo to better understand how collision contributes to voice disorders associated with vocal fold tissue trauma (like nodules and polyps) and to ultimately develop measures that will improve the prevention, diagnosis, and treatment of these disorders (e.g., a vocal fold collision dose).Abstract: A critical element in understanding voice production mechanisms is the characterization of vocal fold collision, which is widely considered a primary etiological factor in the development of common phonotraumatic lesions such as nodules and polyps. This paper describes the development of a transoral, dual-sensor intraglottal/subglottal pressure probe for the simultaneous measurement of vocal fold collision and subglottal pressures during phonation using two miniature sensors positioned 7.6 mm apart at the distal end of a rigid cannula. Proof-of-concept testing was performed using excised whole-mount and hemilarynx human tissue aerodynamically driven into self-sustained oscillation, with systematic variation of the superior-inferior positioning of the vocal fold collision sensor. In the hemilarynx experiment, signals from the pressure sensors were synchronized with an acoustic microphone, a tracheal-surface accelerometer, and two high-speed video cameras recording at 4000 frames per second for top-down and en face imaging of the superior and medial vocal fold surfaces, respectively. As expected, the intraglottal pressure signal exhibited an impulse-like peak when vocal fold contact occurred, followed by a broader peak associated with intraglottal pressure build-up during the de-contacting phase. As subglottal pressure was increased, the peak amplitude of the collision pressure increased and typically reached a value below that of the average subglottal pressure. Results provide important baseline vocal fold collision pressure data with which computational models of voice production can be developed and in vivo measurements can be referenced.

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Section: Comparison Of Results To Prior Worksupporting

confidence: 87%

Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models

et al. 2019

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“…38 The present bioreactor design evolved through several generations of physical replicas of the human larynx built over the past 20 years to mimic phonation, particularly the fold collisions, in vitro. 34,39,40 The oscillation frequency, onset phonatory characteristics, and pressure-versus-flow characteristics of synthetic replicas without inner cavities were previously shown to be in the range of those of human phonation. 22,41 The concept of physical replicas was modified by the introduction of an inner cavity to host the CSM.…”

Section: Bioreactor Conceptmentioning

confidence: 99%

A Flow Perfusion Bioreactor System for Vocal Fold Tissue Engineering Applications

Latifi

Heris

Thomson

et al. 2016

Tissue Engineering Part C: Methods

Self Cite

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The human vocal folds (VFs) undergo complex biomechanical stimulation during phonation. The aim of the present study was to develop and validate a phono-mimetic VF flow perfusion bioreactor, which mimics the mechanical microenvironment of the human VFs in vitro. The bioreactor uses airflow-induced self-oscillations, which have been shown to produce mechanical loading and contact forces that are representative of human phonation. The bioreactor consisted of two synthetic VF replicas within a silicone body. A cell-scaffold mixture (CSM) consisting of human VF fibroblasts, hyaluronic acid, gelatin, and a polyethylene glycol cross-linker was injected into cavities within the replicas. Cell culture medium (CCM) was perfused through the scaffold by using a customized secondary flow loop. After the injection, the bioreactor was operated with no stimulation over a 3-day period to allow for cell adaptation. Phonation was subsequently induced by using a variable speed centrifugal blower for 2 h each day over a period of 4 days. A similar bioreactor without biomechanical stimulation was used as the nonphonatory control. The CSM was harvested from both VF replicas 7 days after the injection. The results confirmed that the phono-mimetic bioreactor supports cell viability and extracellular matrix proteins synthesis, as expected. Many scaffold materials were found to degrade because of challenges from phonation-induced biomechanical stimulation as well as due to biochemical reactions with the CCM. The bioreactor concept enables future investigations of the effects of different phonatory characteristics, that is, voice regimes, on the behavior of the human VF cells. It will also help study the long-term functional outcomes of the VF-specific biomaterials before animal and clinical studies.

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“…An umber of vocalfold and lip replicas, allowing in-vitro investigations on the behaviour of these artificial excitation systems with various conditions of acoustic loads (from av ocal-tract type resonator to abrass instrument resonator)h avebeen used by researchers for the study of excitation mechanisms in voice production and brass instrument playing [5,24,25,26]. Although these systems provide good performance in reproducing the basic functioning of ahuman valve, and in sometimes producing some realistic sounds, theyr emain relatively rough approximations of the complexs tructure of human lips and vocal folds.…”

Section: Objectivesmentioning

confidence: 99%

Synchronous Multimodal Measurements on Lips and Glottis: Comparison Between Two Human-Valve Oscillating Systems

Hézard¹,

Fréour²,

Causse³

et al. 2014

Acta Acustica united with Acustica

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The brass instrument-player and the human voice production systems are both composed of avibrating "human valve" coupled to an acoustic resonator and can be modelled by very similar dynamical systems. Moreover, lips and glottis are both difficult to access during sound production without disturbing their mechanical behaviour and vibration characteristics. In this article, we introduce acommon measurement and analysis framework in order to study and compare the vibration of lips and glottis during sound production. Based on previous studies conducted on vibrating vocal folds, our measurement system is composed of three synchronous measurements -electrical admittance (electroglottographyand electrolabiography),high-speed video recording and sound recording-and allows relatively non-intrusive measurements to be performed on singers and trombone players. Analysis of the collected data highlights the interpretability of electrolabiographic signals. Furthermore, similarities and differences between the twov alves ystems are investigated with regard to high speed imaging, electrical admittance and basic characteristics of the radiated sound. PACS no. 43.70.Jt, 43.75.Fg, 43.75.Rs, 43.75.Yy 1172 ©S.Hirzel Verlag · EAA Hézard et al.:M easurements on lips and glottis ACTA ACUSTICA UNITED WITH ACUSTICA Vol. 100 (2014) ACTA ACUSTICA UNITED WITH ACUSTICA Hézard et al.:M easurements on lips and glottis Vol. 100 (2014) the open area, and the relationship between electrical admittance signals and open area waveforms are explored in section 4.5.

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Verification of two minimally invasive methods for the estimation of the contact pressure in human vocal folds during phonation

Cited by 17 publications

References 26 publications

Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models

Toward Development of a Vocal Fold Contact Pressure Probe: Bench-Top Validation of a Dual-Sensor Probe Using Excised Human Larynx Models

A Flow Perfusion Bioreactor System for Vocal Fold Tissue Engineering Applications

Synchronous Multimodal Measurements on Lips and Glottis: Comparison Between Two Human-Valve Oscillating Systems

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