Verification of exposure to chemical warfare agents through analysis of persistent biomarkers in plants

Bruin-Hoegée, Mirjam de; Lamriti, Latifa; Langenberg, J.P.; Olivier, René C M; Chau, Lai Fun; Schans, M.J. van der; Noort, Daan; Asten, Arian C. van

doi:10.1039/d2ay01650h

Cited by 8 publications

(2 citation statements)

References 37 publications

(52 reference statements)

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“…5 This fact, combined with the knowledge gained from the recent poisoning events regarding the extreme toxicity and stability of these agents, led to the realization that new countermeasures must be developed to effectively tackle Novichoks. 6,7 These include analytical detection, [8][9][10][11][12][13][14][15][16] decontamination (vide infra) methodologies and medical treatments. Structurally, Novichoks resemble the G series more than the V-series of nerve agents, since both Novichoks and G agents possess a uoride leaving group (Fig.…”

Section: Introductionmentioning

confidence: 99%

Acetohydroxamic acid salts: mild, simple and effective degradation reagents to counter Novichok nerve agents

Smolkin,

Nahum,

Bloch-Shilderman

et al. 2024

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Acetohydroxamic acid salts: mild, simple and effective degradation reagents to counter Novichok nerve agents

Smolkin,

Nahum,

Bloch-Shilderman

et al. 2024

RSC Adv.

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“…(Stone 2018 ; BBC News 2018a , b ; Technical Secretariat 2018 ; PHE 2018 ; Technical secretariat 2018 ; Counter Terrorism Policing 2018 ; Vale et al 2018 ; Morris et al 2019 ; Ridley 2019 ; Morris 2021 )…”

Section: Introductionmentioning

confidence: 99%

A-agents, misleadingly known as “Novichoks”: a narrative review

Opravil,

Pejchal,

Finger

et al. 2023

Arch Toxicol

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Abstract“Novichok” refers to a new group of nerve agents called the A-series agents. Their existence came to light in 2018 after incidents in the UK and again in 2020 in Russia. They are unique organophosphorus-based compounds developed during the Cold War in a program called Foliant in the USSR. This review is based on original chemical entities from Mirzayanov's memoirs published in 2008. Due to classified research, a considerable debate arose about their structures, and hence, various structural moieties were speculated. For this reason, the scientific literature is highly incomplete and, in some cases, contradictory. This review critically assesses the information published to date on this class of compounds. The scope of this work is to summarize all the available and relevant information, including the physicochemical properties, chemical synthesis, mechanism of action, toxicity, pharmacokinetics, and medical countermeasures used to date. The environmental stability of A-series agents, the lack of environmentally safe decontamination, their high toxicity, and the scarcity of information on post-contamination treatment pose a challenge for managing possible incidents.

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Smart tool for novichok: a concise review on real-time detection techniques

Sarkar¹,

Das²,

Naha³

2023

Monatsh Chem

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Verification of exposure to chemical warfare agents through analysis of persistent biomarkers in plants

Abstract: Persistent protein adducts were detected in vegetation after exposure to chemical weapons.

Cited by 8 publications

References 37 publications

Acetohydroxamic acid salts: mild, simple and effective degradation reagents to counter Novichok nerve agents

Acetohydroxamic acid salts: mild, simple and effective degradation reagents to counter Novichok nerve agents

A-agents, misleadingly known as “Novichoks”: a narrative review

Smart tool for novichok: a concise review on real-time detection techniques

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