Vergleichende Untersuchungen zur Erythrozytenkinetik und zur Knochenmarksmorphologie bei Patienten mit Osteomyelosklerose und Osteomyelofibrose

Schulz, K; Nowotny, Petra; Bast, G; Preussner, S; Konrad, H; Kiencke, H

doi:10.1159/000208739

Cited by 5 publications

(2 citation statements)

References 7 publications

(8 reference statements)

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“…Quantitative defect of erythropoiesis, as evaluated by PIT (Huff et al, 195 I;Bothwell et al, 1957), is therefore not the cause of anaemia, even in cases with osteomyelosclerosis. O n the other hand, dyserythropoiesis appears to be very frequent in MF, as evidenced by the excessive plasma iron clearance with a low iron incorporation into the red cells (Nathan & Berlin, 1959;Bowdler, 1961;Szur & Smith, 1961;Oettgen & Pribilla, 1964;Brunner, 1965;Gardner & Nathan, 1966;Kesse-Elias et al, 1968;Huber et al, 1969;Lynch et al, 1969;Finch et al, 1970;Schulz et al, 1970;Milner et al, 1973). Surface count patterns, showing in many cases rapid and high splenic 59Fe uptake, and delayed and incomplete release, is other evidence of dyserythropoiesis (Turpin et al, 1971).…”

Section: Erythrokinetic Abnormalitiesmentioning

confidence: 99%

Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

et al. 1978

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Eighty-three patients with myelofibrosis have been studied by erythrokinetics and have been followed up until death or for at least 12 months. Because of a large plasma volume the venous haematocrit gives only a poor idea of the red blood cell volume. The red cell survival was reduced in the majority of cases but significant haemolysis was rare. The amount of haemolysis of autologous and isologous red cells was similar, suggesting an extra-corpuscular origin for the haemolysis. Plasma iron turnover was always increased, sometimes markedly, but red cell iron incorporation was reduced in 70% of cases, indicating ineffective erythropoiesis. Surface counting showed an absence on diminution of sacral iron fixation and a rapid and marked splenic uptake in more than 90% of the cases; uptake of iron by the liver occurred in half the cases, usually not very high; iron release from the spleen was absent or reduced in 67% of the cases. The degree of ineffective erythropoiesis as measured by radio-iron incorporation and release by the spleen, the amount of haemolysis, and the red cell volume were strongly correlated with prognosis. These factors enabled a more precise prediction to be made of the clinical outcome in the 2 years following the study, than the clinical data alone. A prospective study might show whether erythrokinetic studies are also useful in determining the choice of treatment.

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Section: Erythrokinetic Abnormalitiesmentioning

confidence: 99%

Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

et al. 1978

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“…Mässige Verkür zung der Lebensdauer der Erythrozyten wurde bei einem Grossteil der Fälle nachgewiesen [1,3,7,9,12], stärkere organgebundene Haemolysen hingegen scheinen weniger häufig zu sein [6,7], Ferrokinetische Nachuntersuchungen von Patienten wurden von Szur und Smith [12], Brunner [1] Schulz et cd. [11] konnten keine Korrelation zwischen ferrokinetischen Befunden und dem Krankheitsstadium finden. Sie legten dabei ihren Untersuchungen die histologische Stadieneinteilung von Oechslin [8], der in fibroosteoklatisches, ein osteoidoplastisches und ein osteo plastisches Stadium unterscheidet, zugrunde.…”

Section: Resultateunclassified

Versuch einer Stadieneinteilung der Osteomyelosklerose nach ferrokinetischen Befunden

Neumann¹

1976

Acta Haematol

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By means of ferrokinetic investigations three different stages of myelosclerosis can be defined: stage I with shortened plasma iron disappearance half-time, increased plasma iron turnover and normal activities in surface-scanning; stage II with ferrokinetically detectable extrameduUary erythropoiesis and normal utilisation of plasma iron; stage III with ineffective erythropoiesis. This classification seems to correlate better with the clinical course of the disease than the histological staging and, furthermore, seems to have some prognostic relevance.

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Das erythrozytäre System

Montz¹

1978

Nuklearmedizin / Nuclear Medicine

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Vergleichende Untersuchungen zur Erythrozytenkinetik und zur Knochenmarksmorphologie bei Patienten mit Osteomyelosklerose und Osteomyelofibrose

Cited by 5 publications

References 7 publications

Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

Erythrokinetic Studies in Myelofibrosis: Their Significance for Prognosis

Versuch einer Stadieneinteilung der Osteomyelosklerose nach ferrokinetischen Befunden

Das erythrozytäre System

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