Vergleichende Untersuchungen über die Toxizität von Phenacetin und N-Acetyl-p-aminophenol

Vest, M

doi:10.1055/s-0028-1114069

Cited by 10 publications

(2 citation statements)

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“…It is doubtful" 4 whether abnormal hemo globins play much part in the pathogenesis of anemia (except in children 156,186). It has been proposed 29 that p-phenetidine, wruch may be formed depending on the extent to which phenacetin is deacetylated rather than de-ethylated, is the precursor of the substances which oxidize hemoglobin to methemoglobin.…”

Section: Toxicity Attributed To Phenacetinmentioning

confidence: 99%

Phenacetin, through the looking glass

Shelley¹

1967

Clin Pharma and Therapeutics

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World literature on renal damage whieh has been attributed to phenacetin is reviewed and evaluated, together with ineidental effeets of the drug on other organ systems. Renal damage due to single drugs is found to be a rarity, and epidemiologieal, pathologieal, and elinieal data are often inadequate to provide a firm basis for the eoneept of "phenaeetin nephropathy." Partieular note is made of possible toxieity of other eommon eonstituents of analgesie mixtures and the meehanisms of renal damage. Animal experimental data is eollated and eompared, and the inadequaey of mueh experimental work is noted. More work, partieularly in the field of epidemiology, and further investigation of individual variation in metabolizing phenaeetin and other eommonly used analgesies are required. A note on existing legislation with regard to phenaeetin‐eontaining analgesies eoncludes the review.

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Section: Toxicity Attributed To Phenacetinmentioning

confidence: 99%

Phenacetin, through the looking glass

Shelley¹

1967

Clin Pharma and Therapeutics

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“…T his explains th e to x ic side effects (m ethem oglobinem ia, fo rm a tio n of H einz bodies, etc.) of even m ode ra te doses o f acetan ilid e or p h e n a c e tin in young in fa n ts [32].…”

Section: The Form Ation O F Glucuronidesmentioning

confidence: 99%