Vergleichende Untersuchung zur Therapie des evaporativen trockenen Auges

Khaireddin, R.; Kg, Schmidt

doi:10.1055/s-0028-1109686

Cited by 23 publications

(8 citation statements)

References 20 publications

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“…Our results are in good agreement with the results of Korb and others [11][12][13][14][15][16][17] that artificial tears containing phosphatidylcholine and other phospholipids strongly increase the thickness and the non-invasive break-up time of TF in vivo.…”

Section: Discussionsupporting

confidence: 92%

“…At present they are used as compounds of artificial tears (Tears Again, Soothe, Refresh Dry Eye Therapy, FreshKote, Refresh Endura) targeted to replenish the TF lipid layer of patients with Dry Eye Syndrome. Although the number of lipid-containing artificial tears on the market still remains relatively limited, in vivo studies demonstrated that formulations containing phospholipids and other PLs significantly increase the non-invasive break-up time of TF in laboratory animals and humans [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

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Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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a b s t r a c tThe surface interactions of Meibomian gland secretion (MGS) with polar lipid (PL), Egg Sphingomyelin (SM) or Dipalmitoylphosphatidylcholine (DPPC), are studied in mixed pseudo-binary films formed at the air/water interface of Langmuir surface balance. The behavior of the mixed films during slow quasi-equilibrium compression and during fast dynamic compression-decompression is registered by measurements of surface pressure and surface potential, and by monitoring film morphology with Brewster Angle Microscopy (BAM). Quasi-equilibrium compression isotherms are used to calculate the excess Gibbs and Helmholtz energy of mixing between MGS and PLs and thus to evaluate the interactions between the lipid compounds at the interface. The effects of PLs on the mixed film's elastic moduli of area compressibility, morphology and capability to attain high surface pressures are also examined.PLs interact with MGS with different strength and in different manner: MGS-SM interaction is weak and might lead to interfacial disaggregation of the thick meibium domains when SM is in excess, while MGS-DPPC interaction is strong and results in the formation of thick lipid aggregates. Both PLs increase the mixed films reciprocal compressibility and capability to achieve higher surface pressures. The results demonstrate that in vitro studies of the surface interactions between MGS and PLs might be beneficial in the selection of PLs for artificial tear formulations and for examination on molecular scale of the possible role of PLs at the ocular surface.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Georgiev

Kutsarova

Jordanova

et al. 2010

Colloids and Surfaces B: Biointerfaces

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“…Similar to the findings by Böhm et al [6], the safety and tolerability of the treatment investigated here can be assessed as good, since no treatment-related adverse events or serious adverse events occurred. These results are consistent with those from previous studies evaluating the effect of LS for dry eye [8, 10] and with findings from studies assessing liposomal nasal spray [13, 15]. …”

Section: Discussionsupporting

confidence: 83%

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing

Grzella

Schleicher

Shah‐Hosseini

et al. 2019

Int Arch Allergy Immunol

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Background: Liposomal eye spray (LS) has been introduced for the treatment of dry eye. Whether LS can also relieve symptoms due to allergic rhinoconjunctivitis (ARC) has not yet been sufficiently investigated. Objectives: The aim of this study was to assess the onset of action, the reduction of allergy symptoms, and the safety of LS – a nonpharmacological treatment option – compared with those of antihistamine eye drops (AD). Methods: In this open, prospective, controlled, monocenter noninterventional study, adults with ARC received either LS or AD for the relief of eye irritation after a positive conjunctival provocation test (CPT). All patients completed a questionnaire before and after the CPT. Eye irritation was rated on a visual analogue scale (VAS) at 6 time points. Conjunctival redness was analyzed using objective digital analysis based on images taken during the study visit. Results: Data were collected from 40 patients (20 per group). In both groups, 80% of patients perceived an onset of action within 0–2 min after application of LS or AD following the CPT. Relief of eye irritation (as determined by VAS) increased throughout the visit for both groups. In the digital analysis, the mean proportion of redness of the eye decreased from 10.3 to 7.0% for LS and from 10.4 to 6.5% for AD, with the largest difference observed 10 min after application (LS: 8.9%; AD: 6.0%; p = 0.094). Conclusions: LS is a nonpharmacological treatment option for ARC, showing no significant difference or relevant numerical inferiority to AD in any parameter studied. It was generally safe and well tolerated.

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“…Numbers above the arrows represent the different studies on a time scale of their duration in months. 1: current results, 2: Höh et al [ 21 ], 3: group 1 and 2 of Dausch et al [ 20 ], 4: Khaireddin et al [ 22 ], 5: Lee et al [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study

Kiss

Németh

2015

PLoS ONE

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Dry eye complaints are ranked as the most frequent symptoms of patients visiting ophthalmologists. Conjunctivochalasis is a common dry eye disorder, which can cause an unstable tear film and ocular discomfort. The severe conjunctivochalasis characterized by high LId-Parallel COnjunctival Folds (LIPCOF) degree usually requires surgical intervention, where a conservative therapy would be highly desirable. Here we examined the efficacy of a preservative-free, inorganic salt-free unit-dose artificial tear, called Conheal containing isotonic glycerol and 0.015% sodium hyaluronate in a prospective, unmasked, self-controlled study involving 20 patients. The regular use of the glycerol/hyaluronate artificial tear in three months caused a significant improvement in the recorded parameters. Conjunctivochalasis decreased from a mean LIPCOF degree of 2.9±0.4 on both eyes to 1.4±0.6 on the right (median decrease of -2 points, 95% CI from -2.0 to -1.0), and to 1.4±0.7 on the left eye (median decrease of -1 points, 95% CI from -2.0 to -1.0) (p<0.001 for both sides). The tear film breakup time (TFBUT) lengthened from 4.8±1.9 seconds on both eyes to 5.9±2.3 seconds (mean increase of 1.1 seconds, 95% CI from 0.2 to 2.0) and 5.7±1.8 seconds (mean increase of 0.9 seconds, 95% CI from 0.3 to 1.5) on the right and left eyes, respectively (pright eyes = 0.020, pleft eyes = 0.004). The corneal lissamine staining (Oxford Scheme grade) was reduced from 1.3±0.6 on the right and 1.4±0.6 on the left eye significantly (p<0.001) to 0.3±0.4 and 0.2±0.4 on the right and the left eyes. The Ocular Surface Disease Index (OSDI) questionnaire score indicating the subjective complaints of the patients also decreased from a mean value of 36.2±25.3 to 15.6±16.7 (p<0.001). In this study, the artificial tear, Conheal decreased the grade of the conjunctivochalasis significantly after one month of regular use already, from the LIPCOF degree 3, considered as indication of conjunctival surgery, to a LIPCOF degree 2 or lower requiring a conservative therapy. Our results raise the possibility that vision-related quality of life can be significantly improved by conservative therapies even in severe conjunctivochalasis.Trial RegistrationControlled-Trials.com ISRCTN81112701 http://www.isrctn.com/ISRCTN81112701

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Vergleichende Untersuchung zur Therapie des evaporativen trockenen Auges

Cited by 23 publications

References 20 publications

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Interactions of Meibomian gland secretion with polar lipids in Langmuir monolayers

Liposomal Eye Spray Is as Effective as Antihistamine Eye Drops in Patients with Allergic Rhinoconjunctivitis Induced by Conjunctival Provocation Testing

Isotonic Glycerol and Sodium Hyaluronate Containing Artificial Tear Decreases Conjunctivochalasis after One and Three Months: A Self-Controlled, Unmasked Study

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