Vergleichende Untersuchung des prostataspezifischen Antigens und der prostataspezifischen sauren Phosphatase in der Diagnostik und Verlaufskontrolle des Prostatakarzinoms

Wirth, Manfred P.; Grups, J. W.; Frohmüller, H.

doi:10.1007/978-3-642-83170-6_46

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1992

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Cited by 2 publications

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“…In stage pT2pNoM0, only 6 of 66 patients (9.1 %) showed ele vated PAP serum levels in comparison to 47 of the 66 patients (71.2%) in whom elevated PSA levels were de tected. Similar results were reported previously from our institution [20,21]. Thus, PAP obviously is of no value in detecting early prostatic cancer.…”

Section: Discussionsupporting

confidence: 81%

Prostate-Specific Antigen and Prostatic Acid Phosphatase in the Detection of Early Prostate Cancer and in the Prediction of Regional Lymph Node Métastasés

Wirth

Frohmüller²

1992

Eur Urol

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Section: Discussionsupporting

confidence: 81%

Prostate-Specific Antigen and Prostatic Acid Phosphatase in the Detection of Early Prostate Cancer and in the Prediction of Regional Lymph Node Métastasés

Wirth

Frohmüller²

1992

Eur Urol

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“…In stage pT2pN0M0, only 6 of 66 patients (9.1 %) showed ele vated PAP serum levels in comparison to 47 of the 66 patients (71.2%) in whom elevated PSA levels were de tected. Similar results were reported previously by our institution [20,21]. thus, PAP obviously is of no value in detecting early prostatic cancer.…”

Section: Wirth/frohmiillersupporting

confidence: 81%

Prostate-Specific Antigen and Prostate Acid Phosphatase in the Detection of Early Prostate Cancer and the Prediction of Regional Lymph Node Metastases

Wirth¹,

Frohmüller²

1992

Eur Urol

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Serum values of prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) were determined in 180 patients prior to pelvic lymphadenectomy and radical prostatectomy and in 40 patients prior to pelvic lymphadenectomy alone. In all tumor stages, PSA was superior to PAP in detecting cancer of the prostate. By PSA determination using a cutoff level of 4 ng/ml (Tandem^® assay), 28.8 % of the patients with prostate cancer, stage pT(2)pN(o)M(o), and 17.8% of the cases with a stage pT(3)PN(0)M(0) tumor could not be detected. All these tumors had been noticed, however, by digital rectal examination. This indicates that PSA determination cannot replace digital rectal examination as a screening method for prostate cancer. In this study, it was possible neither by PSA nor by PAP to define a practicable cutoff level for patients with and without lymph node métastasés. A clear differentiation between the stages pT(2)pN(0)M(0) and pT(3)pN(0)M(0) was not possible by either PSA or PAP alone.

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Vergleichende Untersuchung des prostataspezifischen Antigens und der prostataspezifischen sauren Phosphatase in der Diagnostik und Verlaufskontrolle des Prostatakarzinoms

Cited by 2 publications

References 4 publications

Prostate-Specific Antigen and Prostatic Acid Phosphatase in the Detection of Early Prostate Cancer and in the Prediction of Regional Lymph Node Métastasés

Prostate-Specific Antigen and Prostatic Acid Phosphatase in the Detection of Early Prostate Cancer and in the Prediction of Regional Lymph Node Métastasés

Prostate-Specific Antigen and Prostate Acid Phosphatase in the Detection of Early Prostate Cancer and the Prediction of Regional Lymph Node Metastases

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