Vergleichende Studie des Einsatzes von Erythropoietin (i.v. vs. s.c.) zur Korrektur der renalen Anämie

Stein, G.; Sperschneider, H; Thieler, H; Dutz, W; Hans, S.; Voigt, Daniela; Marx, Manfred; Engelmann, J; Scigalla, P.

doi:10.1007/978-3-642-76708-1_4

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“…No changes in the number of circulating neutrophils, monocytes and lymphocytes in hemodialysis patients treated with rhu-EPO were observed by Hernandez et al [ 17] and our group [18], A decrease in the number of lymphocytes during rhu-EPO therapy has been described by Berglund and Ekblom [19] in healthy males.…”

Section: Discussionmentioning

confidence: 77%

Influence of Recombinant Human Erythropoietin Therapy on in vivo Chemotaxis and in vitro Phagocytosis of Polymorphonuclear Cells of Hemodialysis Patients

Sperschneider

Neumann²,

Ruffert³

et al. 1996

Blood Purif

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Recombinant human erythropoietin (rhu-EPO) mainly stimulates erythropoiesis, but also influences the production and function of polymorphonuclear granulocytes (PAN). We evaluated the influence of rhu-EPO therapy in patients on maintenance hemodialysis without iron overload on both phagocytic and chemotactic activity of polymorphonuclear leukocytes (PMN) obtained from blood and a skin chamber. The study comprised 28 dialysis patients (15 females, 13 males, age 22-78 years, dialysis sessions three times weekly 4-5 h, mean duration of dialysis treatment 4-99 months) and 20 healthy subjects (9 females, 11 males, age 18-56 years). The absolute number of leukocytes in the peripheral blood, the leukocyte mobilization (chemotactic activity) and the phagocytic activity of PMNs were tested in the patients before (n = 28), and after (n = 18) reaching the target hematocrit of 30% and during the follow-up period. No alteration in the total leukocyte number (PMN, monocytes, lymphocytes) in the peripheral blood during rhu-EPO therapy could be seen. The phagocytic activity of PMNs slightly improved during the follow-up period whereas the decreased chemotactic activity remained unchanged.

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Section: Discussionmentioning

confidence: 77%